Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use

Yeonsuk Ryu, Emma Gracia-Lor, Richard Bade, J. A. Baz-Lomba, Jørgen G. Bramness, Sara Castiglioni, Erika Castrignanò, Ana Causanilles, Adrian Covaci, Pim De Voogt, Felix Hernandez, Barbara Kasprzyk-Hordern, Juliet Kinyua, Ann Kathrin McCall, Christoph Ort, Benedek G. Plósz, Pedram Ramin, Nikolaos I. Rousis, Malcolm J. Reid, Kevin V. Thomas

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Abstract

Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F (8-iso-PGF 2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3′-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF in the 11 cities ranged between 2.5 and 9.9 mg/day/1000 inhabitants with a population-weighted mean of 4.8 mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF 2α, however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF mass load was found to be strongly associated with that of trans-3′-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF as a wastewater biomarker for the assessment of community public health.

Original languageEnglish
Article number39055
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 15 Dec 2016

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    Ryu, Y., Gracia-Lor, E., Bade, R., Baz-Lomba, J. A., Bramness, J. G., Castiglioni, S., Castrignanò, E., Causanilles, A., Covaci, A., De Voogt, P., Hernandez, F., Kasprzyk-Hordern, B., Kinyua, J., McCall, A. K., Ort, C., Plósz, B. G., Ramin, P., Rousis, N. I., Reid, M. J., & Thomas, K. V. (2016). Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use. Scientific Reports, 6, [39055]. https://doi.org/10.1038/srep39055