Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use

Yeonsuk Ryu, Emma Gracia-Lor, Richard Bade, J. A. Baz-Lomba, Jørgen G. Bramness, Sara Castiglioni, Erika Castrignanò, Ana Causanilles, Adrian Covaci, Pim De Voogt, Felix Hernandez, Barbara Kasprzyk-Hordern, Juliet Kinyua, Ann Kathrin McCall, Christoph Ort, Benedek G. Plósz, Pedram Ramin, Nikolaos I. Rousis, Malcolm J. Reid, Kevin V. Thomas

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F (8-iso-PGF 2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3′-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF in the 11 cities ranged between 2.5 and 9.9 mg/day/1000 inhabitants with a population-weighted mean of 4.8 mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF 2α, however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF mass load was found to be strongly associated with that of trans-3′-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF as a wastewater biomarker for the assessment of community public health.

Original languageEnglish
Article number39055
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 15 Dec 2016

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tobacco
biomarker
wastewater
drug
sulfate
epidemiology
public health
ethanol
urbanization
oxidative stress
city
inhabitant

ASJC Scopus subject areas

  • General

Cite this

Ryu, Y., Gracia-Lor, E., Bade, R., Baz-Lomba, J. A., Bramness, J. G., Castiglioni, S., ... Thomas, K. V. (2016). Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use. Scientific Reports, 6, [39055]. https://doi.org/10.1038/srep39055

Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use. / Ryu, Yeonsuk; Gracia-Lor, Emma; Bade, Richard; Baz-Lomba, J. A.; Bramness, Jørgen G.; Castiglioni, Sara; Castrignanò, Erika; Causanilles, Ana; Covaci, Adrian; De Voogt, Pim; Hernandez, Felix; Kasprzyk-Hordern, Barbara; Kinyua, Juliet; McCall, Ann Kathrin; Ort, Christoph; Plósz, Benedek G.; Ramin, Pedram; Rousis, Nikolaos I.; Reid, Malcolm J.; Thomas, Kevin V.

In: Scientific Reports, Vol. 6, 39055, 15.12.2016.

Research output: Contribution to journalArticle

Ryu, Y, Gracia-Lor, E, Bade, R, Baz-Lomba, JA, Bramness, JG, Castiglioni, S, Castrignanò, E, Causanilles, A, Covaci, A, De Voogt, P, Hernandez, F, Kasprzyk-Hordern, B, Kinyua, J, McCall, AK, Ort, C, Plósz, BG, Ramin, P, Rousis, NI, Reid, MJ & Thomas, KV 2016, 'Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use', Scientific Reports, vol. 6, 39055. https://doi.org/10.1038/srep39055
Ryu, Yeonsuk ; Gracia-Lor, Emma ; Bade, Richard ; Baz-Lomba, J. A. ; Bramness, Jørgen G. ; Castiglioni, Sara ; Castrignanò, Erika ; Causanilles, Ana ; Covaci, Adrian ; De Voogt, Pim ; Hernandez, Felix ; Kasprzyk-Hordern, Barbara ; Kinyua, Juliet ; McCall, Ann Kathrin ; Ort, Christoph ; Plósz, Benedek G. ; Ramin, Pedram ; Rousis, Nikolaos I. ; Reid, Malcolm J. ; Thomas, Kevin V. / Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use. In: Scientific Reports. 2016 ; Vol. 6.
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