Increased cardiac output and left ventricular contractility in pigs paced with vs. without restored respiratory sinus arrhythmia - proof of principle of a newly developed pacing device

Martin Riesenhuber; Andreas  Spannbauer; E Hasimbegovic; K Muller-Zlabinger; D Lukovic; K Hamzaraj; E Han; R Hemetsberger; Soren Asmul; Martin Leonhardt; Chandrabhan Kushwah; Alain Nogaret; C Hengstenberg; Mariann Gyongyosi

doi:10.1093/eurheartj/ehad655.3169

Increased cardiac output and left ventricular contractility in pigs paced with vs. without restored respiratory sinus arrhythmia - proof of principle of a newly developed pacing device

Martin Riesenhuber, Andreas Spannbauer, E Hasimbegovic, K Muller-Zlabinger, D Lukovic, K Hamzaraj, E Han, R Hemetsberger, Soren Asmul, Martin Leonhardt, Chandrabhan Kushwah, Alain Nogaret, C Hengstenberg, Mariann Gyongyosi

University of Vienna

Research output: Contribution to journal › Article › peer-review

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Abstract

Heart rate variability (HRV) correlates with the severity and mortality of heart failure. Respiratory sinus arrhythmia (RSA) is defined by the dynamic increase and decrease in heart rate between breaths. Restoration of RSA might be beneficial in patients with heart failure and/or patients in need of permanent pacing. The aim of this translational, proof-of-principle study was to investigate the effect of pacing with or without RSA using a newly designed pacing device on the left ventricular contractility and cardiac output.

Original language	English
Article number	ehad655.3169
Number of pages	4
Journal	European Heart Journal
Volume	44
Issue number	Supplement 2
DOIs	https://doi.org/10.1093/eurheartj/ehad655.3169
Publication status	Published - 9 Nov 2023

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Funding

Funding Acknowledgements: Type of funding sources: Public grant(s) – EU funding. Main funding source(s): European Union’s Horizon 2020 Future Emerging Technologies Programme

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10.1093/eurheartj/ehad655.3169

ESC_article_Martin_Riesenhuber_et_al (accepted author manuscript)
This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal following peer review. The version of record is available online at: https://doi.org/10.1093/eurheartj/ehad655.3169.
Accepted author manuscript, 300 KB

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Riesenhuber, M., Spannbauer, A., Hasimbegovic, E., Muller-Zlabinger, K., Lukovic, D., Hamzaraj, K., Han, E., Hemetsberger, R., Asmul, S., Leonhardt, M., Kushwah, C., Nogaret, A., Hengstenberg, C., & Gyongyosi, M. (2023). Increased cardiac output and left ventricular contractility in pigs paced with vs. without restored respiratory sinus arrhythmia - proof of principle of a newly developed pacing device. European Heart Journal, 44(Supplement 2), Article ehad655.3169. https://doi.org/10.1093/eurheartj/ehad655.3169

Increased cardiac output and left ventricular contractility in pigs paced with vs. without restored respiratory sinus arrhythmia - proof of principle of a newly developed pacing device. / Riesenhuber, Martin; Spannbauer, Andreas ; Hasimbegovic, E et al.
In: European Heart Journal, Vol. 44, No. Supplement 2, ehad655.3169, 09.11.2023.

Research output: Contribution to journal › Article › peer-review

Riesenhuber, M, Spannbauer, A, Hasimbegovic, E, Muller-Zlabinger, K, Lukovic, D, Hamzaraj, K, Han, E, Hemetsberger, R, Asmul, S, Leonhardt, M, Kushwah, C, Nogaret, A, Hengstenberg, C & Gyongyosi, M 2023, 'Increased cardiac output and left ventricular contractility in pigs paced with vs. without restored respiratory sinus arrhythmia - proof of principle of a newly developed pacing device', European Heart Journal, vol. 44, no. Supplement 2, ehad655.3169. https://doi.org/10.1093/eurheartj/ehad655.3169

Riesenhuber M, Spannbauer A, Hasimbegovic E, Muller-Zlabinger K, Lukovic D, Hamzaraj K et al. Increased cardiac output and left ventricular contractility in pigs paced with vs. without restored respiratory sinus arrhythmia - proof of principle of a newly developed pacing device. European Heart Journal. 2023 Nov 9;44(Supplement 2):ehad655.3169. doi: 10.1093/eurheartj/ehad655.3169

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abstract = "Heart rate variability (HRV) correlates with the severity and mortality of heart failure. Respiratory sinus arrhythmia (RSA) is defined by the dynamic increase and decrease in heart rate between breaths. Restoration of RSA might be beneficial in patients with heart failure and/or patients in need of permanent pacing. The aim of this translational, proof-of-principle study was to investigate the effect of pacing with or without RSA using a newly designed pacing device on the left ventricular contractility and cardiac output. ",

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Increased cardiac output and left ventricular contractility in pigs paced with vs. without restored respiratory sinus arrhythmia - proof of principle of a newly developed pacing device

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