Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks

Andrew D. Burrows, Monika Jurcic, Luke L. Keenan, Rebecca A. Lane, Mary F. Mahon, Mark R. Warren, Harriott Nowell, Michael Paradowski, John Spencer

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.
Original languageEnglish
Pages (from-to)11260-11262
Number of pages3
JournalChemical Communications
Volume49
Issue number96
DOIs
Publication statusPublished - 14 Dec 2013

Fingerprint Dive into the research topics of 'Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks'. Together they form a unique fingerprint.

  • Cite this