Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks

Andrew D. Burrows; Monika Jurcic; Luke L. Keenan; Rebecca A. Lane; Mary F. Mahon; Mark R. Warren; Harriott Nowell; Michael Paradowski; John Spencer

doi:10.1039/c3cc45689g

Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks

Andrew D. Burrows, Monika Jurcic, Luke L. Keenan, Rebecca A. Lane, Mary F. Mahon, Mark R. Warren, Harriott Nowell, Michael Paradowski, John Spencer

Research output: Contribution to journal › Article › peer-review

42 Citations (SciVal)

Abstract

A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.

Original language	English
Pages (from-to)	11260-11262
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	96
DOIs	https://doi.org/10.1039/c3cc45689g
Publication status	Published - 14 Dec 2013

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abstract = "A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.",

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AU - Burrows, Andrew D.

AU - Jurcic, Monika

AU - Keenan, Luke L.

AU - Lane, Rebecca A.

AU - Mahon, Mary F.

AU - Warren, Mark R.

AU - Nowell, Harriott

AU - Paradowski, Michael

AU - Spencer, John

PY - 2013/12/14

Y1 - 2013/12/14

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AB - A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.

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Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks

Abstract

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