A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.
Burrows, A. D., Jurcic, M., Keenan, L. L., Lane, R. A., Mahon, M. F., Warren, M. R., Nowell, H., Paradowski, M., & Spencer, J. (2013). Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks. Chemical Communications, 49(96), 11260-11262. https://doi.org/10.1039/c3cc45689g