In vivo study of sustained-release formulations containing amoxicillin and Gelucire 64/02

M. B. Delgado Charro, J. L. Vila Jato

Research output: Contribution to journalArticle

Abstract

Formulations prepared by fluid-bed coating of direct acting granules with Gelucire 64/02 have shown adequate sustained-release properties in vitro. The in vivo study described demonstrates that the amount of unaltered amoxicillin excreted via urine decreases progressively as the ability of the formulations to sustain release increases. No differences are observed in MRT or VRT. The results obtained show the presence of an absorption window for this aminopenicillin. An assessment is made of the topographic representations proposed by various authors to predict the in vivo behaviour of controlled-release formulations and also potential problems in the bioavailability.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume78
Issue number1-3
DOIs
Publication statusPublished - 1 Jan 1992

Keywords

  • Absorption window
  • Amoxicillin
  • Fluid-bed coating
  • Gelucire
  • Sustained release
  • Topographical dissolution characterization

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