TY - JOUR
T1 - In vivo methods for the assessment of topical drug bioavailability
AU - Herkenne, C
AU - Alberti, I
AU - Naik, A
AU - Kalia, Y N
AU - Mathy, F X
AU - Préat, V
AU - Guy, R H
N1 - Fulltext freely available from PubMed Central via the link shown above.
PY - 2008/1
Y1 - 2008/1
N2 - This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of the predictive calculations, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.
AB - This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of the predictive calculations, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.
KW - dermatopharmacokinetics.
KW - tape stripping
KW - Cutaneous bioavailability
KW - microdialysis
KW - cutaneous drug concentration
UR - http://www.scopus.com/inward/record.url?scp=38049129770&partnerID=8YFLogxK
UR - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2217624
UR - http://dx.doi.org/10.1007/s11095-007-9429-7
U2 - 10.1007/s11095-007-9429-7
DO - 10.1007/s11095-007-9429-7
M3 - Article
SN - 0724-8741
VL - 25
SP - 87
EP - 103
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 1
ER -