In vivo methods for the assessment of topical drug bioavailability

C Herkenne, I Alberti, A Naik, Y N Kalia, F X Mathy, V Préat, R H Guy

Research output: Contribution to journalArticle

153 Citations (Scopus)
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Abstract

This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of the predictive calculations, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.
Original languageEnglish
Pages (from-to)87-103
Number of pages17
JournalPharmaceutical Research
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • dermatopharmacokinetics.
  • tape stripping
  • Cutaneous bioavailability
  • microdialysis
  • cutaneous drug concentration

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