In vivo colonization profile study of Bordetella bronchiseptica in the nasal cavity

Yasuhiko Irie, Ming H Yuk

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Bordetella bronchiseptica chronically infects a wide range of mammals, and resides primarily in the nasal cavity of the infected host. Multiple virulence factors of Bordetella species have been studied in the context of lower respiratory tract infections, but relatively less is known about the bacterial life cycle in the nasal cavity. Evidences were discovered for Bvg intermediate (Bvg(i)) phase expression in vivo and that the major adhesin filamentous hemagglutinin plays a major role in the colonization of B. bronchiseptica in the unciliated olfactory epithelia of the nasal cavity.
Original languageEnglish
Pages (from-to)191-198
Number of pages8
JournalFEMS Microbiology Letters
Volume275
Issue number2
DOIs
Publication statusPublished - Oct 2007

Keywords

  • Adhesins, Bacterial
  • Animals
  • Bacterial Proteins
  • Bordetella Infections
  • Bordetella bronchiseptica
  • Epithelium
  • Gene Expression Regulation, Bacterial
  • Mice
  • Mice, Inbred C57BL
  • Nasal Cavity
  • Trans-Activators
  • Virulence Factors, Bordetella

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