In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose

N. Garcia-Gonzalez; null Blanco-Fuente; S. Anguiano-Igea; B. Delgado-Charro; F. J. Otero-Espinar; J. Blanco-Mendez

In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose

N. Garcia-Gonzalez, Blanco-Fuente, S. Anguiano-Igea, B. Delgado-Charro, F. J. Otero-Espinar, J. Blanco-Mendez

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of derivatives of acrylic acid (PAA), Carbopol 907, 941, 934 and 940, and hydroxypropyl methylcellulose (HPMC) on metoclopramide release from bioadhesive tablets designed for buccal use has been studied. Both the PAA/HPMC ratio and the molecular weight of the Carbopol gave statistically significant differences in drug release. The swelling and wettability of the tablets were also investigated, since these two factors influence release. Turbidity and viscosity studies revealed the formation of a complex between PAA and HPMC. The greater the turbidity due to the formation of the complex, the lower the degree of swelling. The release obtained for Carbopol 934 is greater compared with Carbopol 941 and 940, possibly due to the lower viscosity of the Carbopol. Nevertheless, the behaviour in solution is more influenced by the hydrophilic nature of the HPMC than by the formation of the complex.

Original language	English
Pages (from-to)	494-499
Number of pages	6
Journal	STP Pharma Sciences
Volume	2
Issue number	6
Publication status	Published - 1992

Cite this

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title = "In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose",

abstract = "The influence of derivatives of acrylic acid (PAA), Carbopol 907, 941, 934 and 940, and hydroxypropyl methylcellulose (HPMC) on metoclopramide release from bioadhesive tablets designed for buccal use has been studied. Both the PAA/HPMC ratio and the molecular weight of the Carbopol gave statistically significant differences in drug release. The swelling and wettability of the tablets were also investigated, since these two factors influence release. Turbidity and viscosity studies revealed the formation of a complex between PAA and HPMC. The greater the turbidity due to the formation of the complex, the lower the degree of swelling. The release obtained for Carbopol 934 is greater compared with Carbopol 941 and 940, possibly due to the lower viscosity of the Carbopol. Nevertheless, the behaviour in solution is more influenced by the hydrophilic nature of the HPMC than by the formation of the complex.",

author = "N. Garcia-Gonzalez and Blanco-Fuente and S. Anguiano-Igea and B. Delgado-Charro and Otero-Espinar, {F. J.} and J. Blanco-Mendez",

year = "1992",

language = "English",

volume = "2",

pages = "494--499",

journal = "STP Pharma Sciences",

issn = "1157-1497",

publisher = "Editions de Sante",

number = "6",

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TY - JOUR

T1 - In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose

AU - Garcia-Gonzalez, N.

AU - Blanco-Fuente, null

AU - Anguiano-Igea, S.

AU - Delgado-Charro, B.

AU - Otero-Espinar, F. J.

AU - Blanco-Mendez, J.

PY - 1992

Y1 - 1992

N2 - The influence of derivatives of acrylic acid (PAA), Carbopol 907, 941, 934 and 940, and hydroxypropyl methylcellulose (HPMC) on metoclopramide release from bioadhesive tablets designed for buccal use has been studied. Both the PAA/HPMC ratio and the molecular weight of the Carbopol gave statistically significant differences in drug release. The swelling and wettability of the tablets were also investigated, since these two factors influence release. Turbidity and viscosity studies revealed the formation of a complex between PAA and HPMC. The greater the turbidity due to the formation of the complex, the lower the degree of swelling. The release obtained for Carbopol 934 is greater compared with Carbopol 941 and 940, possibly due to the lower viscosity of the Carbopol. Nevertheless, the behaviour in solution is more influenced by the hydrophilic nature of the HPMC than by the formation of the complex.

AB - The influence of derivatives of acrylic acid (PAA), Carbopol 907, 941, 934 and 940, and hydroxypropyl methylcellulose (HPMC) on metoclopramide release from bioadhesive tablets designed for buccal use has been studied. Both the PAA/HPMC ratio and the molecular weight of the Carbopol gave statistically significant differences in drug release. The swelling and wettability of the tablets were also investigated, since these two factors influence release. Turbidity and viscosity studies revealed the formation of a complex between PAA and HPMC. The greater the turbidity due to the formation of the complex, the lower the degree of swelling. The release obtained for Carbopol 934 is greater compared with Carbopol 941 and 940, possibly due to the lower viscosity of the Carbopol. Nevertheless, the behaviour in solution is more influenced by the hydrophilic nature of the HPMC than by the formation of the complex.

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M3 - Article

AN - SCOPUS:0027052791

SN - 1157-1497

VL - 2

SP - 494

EP - 499

JO - STP Pharma Sciences

JF - STP Pharma Sciences

IS - 6

ER -

In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose

Abstract

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