In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose

N. Garcia-Gonzalez, Blanco-Fuente, S. Anguiano-Igea, B. Delgado-Charro, F. J. Otero-Espinar, J. Blanco-Mendez

Research output: Contribution to journalArticle

Abstract

The influence of derivatives of acrylic acid (PAA), Carbopol 907, 941, 934 and 940, and hydroxypropyl methylcellulose (HPMC) on metoclopramide release from bioadhesive tablets designed for buccal use has been studied. Both the PAA/HPMC ratio and the molecular weight of the Carbopol gave statistically significant differences in drug release. The swelling and wettability of the tablets were also investigated, since these two factors influence release. Turbidity and viscosity studies revealed the formation of a complex between PAA and HPMC. The greater the turbidity due to the formation of the complex, the lower the degree of swelling. The release obtained for Carbopol 934 is greater compared with Carbopol 941 and 940, possibly due to the lower viscosity of the Carbopol. Nevertheless, the behaviour in solution is more influenced by the hydrophilic nature of the HPMC than by the formation of the complex.

Original languageEnglish
Pages (from-to)494-499
Number of pages6
JournalSTP Pharma Sciences
Volume2
Issue number6
Publication statusPublished - 1992

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carbopol 940
Metoclopramide
Cheek
Tablets
Viscosity
Wettability
Molecular Weight
In Vitro Techniques
Hypromellose Derivatives

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In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose. / Garcia-Gonzalez, N.; Blanco-Fuente; Anguiano-Igea, S.; Delgado-Charro, B.; Otero-Espinar, F. J.; Blanco-Mendez, J.

In: STP Pharma Sciences, Vol. 2, No. 6, 1992, p. 494-499.

Research output: Contribution to journalArticle

Garcia-Gonzalez, N, Blanco-Fuente, Anguiano-Igea, S, Delgado-Charro, B, Otero-Espinar, FJ & Blanco-Mendez, J 1992, 'In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose', STP Pharma Sciences, vol. 2, no. 6, pp. 494-499.
Garcia-Gonzalez, N. ; Blanco-Fuente ; Anguiano-Igea, S. ; Delgado-Charro, B. ; Otero-Espinar, F. J. ; Blanco-Mendez, J. / In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose. In: STP Pharma Sciences. 1992 ; Vol. 2, No. 6. pp. 494-499.
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