Sarah Bailey, Tobias Bast, Lauren Chaby, Bruce Kinon, Michael Harte, Sally Mead, Rachel Moloney, Ian Ragan, Clare Stanford, Mark Tricklebank, Mark Zervas, Laura Ajram

Research output: Contribution to journalArticlepeer-review


A working group of fourteen volunteers, comprising an international team of researchers from academia and industry, with expertise in behavioural studies of animal models, convened in 2021 to discuss how to improve the translational relevance and interpretation of findings from animal models that are used in preclinical psychopharmacology to study mechanisms and potential treatments of psychiatric disorders.

The following paper distils the outcomes of the working group’s discussions into 10 key considerations for the planning and reporting of behavioural studies in animal models relevant to psychiatric disorders. These form the iTRIPP guidelines (Improving Translational Relevance In Preclinical Psychopharmacology).

These guidelines reflect the key considerations that the group thinks will likely have substantial impact in terms of improving the translational relevance of behavioural studies in animal models that are used to study psychiatric disorders and their treatment if taken up by the research community when drafting and reviewing manuscripts, presentations and grant applications. The iTRIPP guidelines are intended to complement general recommendations for planning and reporting animal studies that have been published elsewhere, including the PREPARE and ARRIVE guidelines, enabling researchers to fully consider and select the most appropriate animal model for the purpose and to interpret their findings appropriately. This in turn will increase the clinical benefit of such research and is therefore important not only for the scientific community but also for patients and the lay public
Original languageEnglish
JournalJournal of Psychopharmacology
Publication statusUnpublished - 20 Feb 2023


Dive into the research topics of 'IMPROVING TRANSLATIONAL RELEVANCE IN PRECLINICAL PSYCHOPHARMACOLOGY (iTRIPP)'. Together they form a unique fingerprint.

Cite this