Improved sib‐pair linkage test for disease susceptibility loci

Julian J. Faraway

doi:10.1002/gepi.1370100403

Improved sib‐pair linkage test for disease susceptibility loci

Julian J. Faraway

University of Michigan

Research output: Contribution to journal › Article › peer-review

Abstract

An improved sib‐pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi‐squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact power comparisons are made with the previously proposed tests. The new test is shown to be more powerful for finite samples as well as being asymptotically uniformly most powerful. © 1993 Wiley‐Liss, Inc.

Original language	English
Pages (from-to)	225-233
Number of pages	9
Journal	Genetic Epidemiology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1002/gepi.1370100403
Publication status	Published - 1 Jan 1993

Keywords

chi‐squared goodness of fit statistic
most powerful test
sib‐pair method

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

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10.1002/gepi.1370100403

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Improved sib‐pair linkage test for disease susceptibility loci

Abstract

Keywords

ASJC Scopus subject areas

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