Improved sib‐pair linkage test for disease susceptibility loci

Research output: Contribution to journalArticle

Abstract

An improved sib‐pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi‐squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact power comparisons are made with the previously proposed tests. The new test is shown to be more powerful for finite samples as well as being asymptotically uniformly most powerful. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)225-233
Number of pages9
JournalGenetic Epidemiology
Volume10
Issue number4
DOIs
Publication statusPublished - 1 Jan 1993

Keywords

  • chi‐squared goodness of fit statistic
  • most powerful test
  • sib‐pair method

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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