Impact of Exercise on Cardiometabolic Component Risks in Spinal Cord Injured Humans

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: Spinal cord injury (SCI) creates a complex pathology, characterised by low levels of habitual physical activity and an increased risk of cardiometabolic disease. This study aimed to assess the impact of a moderate-intensity upper-body exercise training intervention on, biomarkers of cardiometabolic component risks, adipose tissue metabolism and cardiorespiratory fitness in persons with SCI. 
Methods: Twenty-one inactive men and women with chronic (>1 year) SCI (all paraplegic injuries), aged 47 ± 8 years (mean ± S.D), were randomly allocated to either a 6-week prescribed home-based exercise intervention (INT; n = 13) or control group (CON; n = 8). Participants assigned to the exercise group completed 4 x 45-min moderate-intensity (60-65% peak oxygen uptake (V̇˙O2peak)) arm-crank exercise sessions per week. At baseline and follow-up, fasted and post-load blood samples (collected during oral glucose tolerance tests) were obtained to measure metabolic regulation and biomarkers of cardiovascular disease. Abdominal subcutaneous adipose tissue biopsies were also obtained and cardiorespiratory fitness assessed.
Results: Compared to CON, INT significantly decreased (P = 0.04) serum fasting insulin (Δ, CON 3.1 ± 10.7 pmol·l-1; INT, -12.7 ± 18.7) and homeostasis model assessment of insulin resistance (HOMA2-IR Δ, CON 0.06 ± 0.20; INT, -0.23 ± 0.36). The exercise group also increased V̇˙O2peak (Δ, 3.4 ml·kg-1·min-1, P ≤ 0.001). Adipose tissue metabolism, composite Insulin Sensitivity Index (C-ISIMatsuda) and other cardiovascular disease risk biomarkers were not different between groups. 
Conclusion: Moderate-intensity upper-body exercise improved aspects of metabolic regulation and cardiorespiratory fitness. Changes in fasting insulin and HOMA2-IR, but not C-ISIMatsuda, suggest improved hepatic but not peripheral insulin sensitivity following 6 weeks of exercise training in persons with chronic paraplegia.
Original languageEnglish
Pages (from-to)2469–2477
Number of pages8
JournalMedicine & Science in Sports & Exercise
Volume42
Issue number12
Early online date28 Jul 2017
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Spinal Cord
Exercise
Spinal Cord Injuries
Insulin Resistance
Biomarkers
Adipose Tissue
Fasting
Cardiovascular Diseases
Abdominal Subcutaneous Fat
Insulin
Paraplegia
Glucose Tolerance Test
Homeostasis
Pathology
Oxygen
Biopsy
Control Groups
iodonitrotetrazolium
Liver
Wounds and Injuries

Keywords

  • GENE EXPRESSION
  • INSULIN SENSITIVITY
  • PARAPLEGIA
  • MODERATE-INTENSITY EXERCISE
  • METABOLIC HEALTH
  • CARDIOVASCULAR FITNESS

Cite this

Impact of Exercise on Cardiometabolic Component Risks in Spinal Cord Injured Humans. / Nightingale, Tom; Walhin, Jean-Philippe; Thompson, Dylan; Bilzon, James.

In: Medicine & Science in Sports & Exercise, Vol. 42, No. 12, 01.12.2017, p. 2469–2477.

Research output: Contribution to journalArticle

@article{4d172f517f264d428ef380eadd7925c5,
title = "Impact of Exercise on Cardiometabolic Component Risks in Spinal Cord Injured Humans",
abstract = "Purpose: Spinal cord injury (SCI) creates a complex pathology, characterised by low levels of habitual physical activity and an increased risk of cardiometabolic disease. This study aimed to assess the impact of a moderate-intensity upper-body exercise training intervention on, biomarkers of cardiometabolic component risks, adipose tissue metabolism and cardiorespiratory fitness in persons with SCI. Methods: Twenty-one inactive men and women with chronic (>1 year) SCI (all paraplegic injuries), aged 47 ± 8 years (mean ± S.D), were randomly allocated to either a 6-week prescribed home-based exercise intervention (INT; n = 13) or control group (CON; n = 8). Participants assigned to the exercise group completed 4 x 45-min moderate-intensity (60-65{\%} peak oxygen uptake (V̇˙O2peak)) arm-crank exercise sessions per week. At baseline and follow-up, fasted and post-load blood samples (collected during oral glucose tolerance tests) were obtained to measure metabolic regulation and biomarkers of cardiovascular disease. Abdominal subcutaneous adipose tissue biopsies were also obtained and cardiorespiratory fitness assessed.Results: Compared to CON, INT significantly decreased (P = 0.04) serum fasting insulin (Δ, CON 3.1 ± 10.7 pmol·l-1; INT, -12.7 ± 18.7) and homeostasis model assessment of insulin resistance (HOMA2-IR Δ, CON 0.06 ± 0.20; INT, -0.23 ± 0.36). The exercise group also increased V̇˙O2peak (Δ, 3.4 ml·kg-1·min-1, P ≤ 0.001). Adipose tissue metabolism, composite Insulin Sensitivity Index (C-ISIMatsuda) and other cardiovascular disease risk biomarkers were not different between groups. Conclusion: Moderate-intensity upper-body exercise improved aspects of metabolic regulation and cardiorespiratory fitness. Changes in fasting insulin and HOMA2-IR, but not C-ISIMatsuda, suggest improved hepatic but not peripheral insulin sensitivity following 6 weeks of exercise training in persons with chronic paraplegia.",
keywords = "GENE EXPRESSION, INSULIN SENSITIVITY , PARAPLEGIA , MODERATE-INTENSITY EXERCISE , METABOLIC HEALTH , CARDIOVASCULAR FITNESS",
author = "Tom Nightingale and Jean-Philippe Walhin and Dylan Thompson and James Bilzon",
year = "2017",
month = "12",
day = "1",
doi = "10.1249/MSS.0000000000001390",
language = "English",
volume = "42",
pages = "2469–2477",
journal = "Medicine & Science in Sports & Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams & Wilkins",
number = "12",

}

TY - JOUR

T1 - Impact of Exercise on Cardiometabolic Component Risks in Spinal Cord Injured Humans

AU - Nightingale, Tom

AU - Walhin, Jean-Philippe

AU - Thompson, Dylan

AU - Bilzon, James

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Purpose: Spinal cord injury (SCI) creates a complex pathology, characterised by low levels of habitual physical activity and an increased risk of cardiometabolic disease. This study aimed to assess the impact of a moderate-intensity upper-body exercise training intervention on, biomarkers of cardiometabolic component risks, adipose tissue metabolism and cardiorespiratory fitness in persons with SCI. Methods: Twenty-one inactive men and women with chronic (>1 year) SCI (all paraplegic injuries), aged 47 ± 8 years (mean ± S.D), were randomly allocated to either a 6-week prescribed home-based exercise intervention (INT; n = 13) or control group (CON; n = 8). Participants assigned to the exercise group completed 4 x 45-min moderate-intensity (60-65% peak oxygen uptake (V̇˙O2peak)) arm-crank exercise sessions per week. At baseline and follow-up, fasted and post-load blood samples (collected during oral glucose tolerance tests) were obtained to measure metabolic regulation and biomarkers of cardiovascular disease. Abdominal subcutaneous adipose tissue biopsies were also obtained and cardiorespiratory fitness assessed.Results: Compared to CON, INT significantly decreased (P = 0.04) serum fasting insulin (Δ, CON 3.1 ± 10.7 pmol·l-1; INT, -12.7 ± 18.7) and homeostasis model assessment of insulin resistance (HOMA2-IR Δ, CON 0.06 ± 0.20; INT, -0.23 ± 0.36). The exercise group also increased V̇˙O2peak (Δ, 3.4 ml·kg-1·min-1, P ≤ 0.001). Adipose tissue metabolism, composite Insulin Sensitivity Index (C-ISIMatsuda) and other cardiovascular disease risk biomarkers were not different between groups. Conclusion: Moderate-intensity upper-body exercise improved aspects of metabolic regulation and cardiorespiratory fitness. Changes in fasting insulin and HOMA2-IR, but not C-ISIMatsuda, suggest improved hepatic but not peripheral insulin sensitivity following 6 weeks of exercise training in persons with chronic paraplegia.

AB - Purpose: Spinal cord injury (SCI) creates a complex pathology, characterised by low levels of habitual physical activity and an increased risk of cardiometabolic disease. This study aimed to assess the impact of a moderate-intensity upper-body exercise training intervention on, biomarkers of cardiometabolic component risks, adipose tissue metabolism and cardiorespiratory fitness in persons with SCI. Methods: Twenty-one inactive men and women with chronic (>1 year) SCI (all paraplegic injuries), aged 47 ± 8 years (mean ± S.D), were randomly allocated to either a 6-week prescribed home-based exercise intervention (INT; n = 13) or control group (CON; n = 8). Participants assigned to the exercise group completed 4 x 45-min moderate-intensity (60-65% peak oxygen uptake (V̇˙O2peak)) arm-crank exercise sessions per week. At baseline and follow-up, fasted and post-load blood samples (collected during oral glucose tolerance tests) were obtained to measure metabolic regulation and biomarkers of cardiovascular disease. Abdominal subcutaneous adipose tissue biopsies were also obtained and cardiorespiratory fitness assessed.Results: Compared to CON, INT significantly decreased (P = 0.04) serum fasting insulin (Δ, CON 3.1 ± 10.7 pmol·l-1; INT, -12.7 ± 18.7) and homeostasis model assessment of insulin resistance (HOMA2-IR Δ, CON 0.06 ± 0.20; INT, -0.23 ± 0.36). The exercise group also increased V̇˙O2peak (Δ, 3.4 ml·kg-1·min-1, P ≤ 0.001). Adipose tissue metabolism, composite Insulin Sensitivity Index (C-ISIMatsuda) and other cardiovascular disease risk biomarkers were not different between groups. Conclusion: Moderate-intensity upper-body exercise improved aspects of metabolic regulation and cardiorespiratory fitness. Changes in fasting insulin and HOMA2-IR, but not C-ISIMatsuda, suggest improved hepatic but not peripheral insulin sensitivity following 6 weeks of exercise training in persons with chronic paraplegia.

KW - GENE EXPRESSION

KW - INSULIN SENSITIVITY

KW - PARAPLEGIA

KW - MODERATE-INTENSITY EXERCISE

KW - METABOLIC HEALTH

KW - CARDIOVASCULAR FITNESS

U2 - 10.1249/MSS.0000000000001390

DO - 10.1249/MSS.0000000000001390

M3 - Article

VL - 42

SP - 2469

EP - 2477

JO - Medicine & Science in Sports & Exercise

JF - Medicine & Science in Sports & Exercise

SN - 0195-9131

IS - 12

ER -