Impact of Anticholinergic Burden on Cognitive Performance: A Cohort Study of Community-Dwelling Older Adults

Prasad Nishtala; Heather Allore; Ling Han; Hamish Jamieson; Sarah N. Hilmer; Te-Yuan Chyou

doi:10.1016/j.jamda.2020.03.027

Impact of Anticholinergic Burden on Cognitive Performance: A Cohort Study of Community-Dwelling Older Adults

Prasad Nishtala
, Heather Allore
, Ling Han
, Hamish Jamieson
, Sarah N. Hilmer
, Te-Yuan Chyou

Department of Life Sciences

Yale University
University of Otago
Burwood Hospital
University of Sydney

Research output: Contribution to journal › Letter › peer-review

9 Citations (SciVal)

104 Downloads (Pure)

Abstract

Older people are susceptible to the adverse effects of anticholinergic medications, including cognitive impairment. A systematic review of observational studies reported mixed associations between high anticholinergic burden, a cumulative measure of anticholinergic medications, and cognitive performance in older people. Observational studies may have biased estimates of the impact of exposures, as the exposed and unexposed may systematically differ in covariates associated with the outcomes.

Original language	English
Pages (from-to)	1357-1358.e3
Journal	Journal of the American Medical Directors Association
Volume	21
Issue number	9
Early online date	10 May 2020
DOIs	https://doi.org/10.1016/j.jamda.2020.03.027
Publication status	Published - Sept 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Nursing
Health Policy
Geriatrics and Gerontology

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10.1016/j.jamda.2020.03.027

JAMDA-S-20-00248.PDFAccepted author manuscript, 962 KBLicence: CC BY-NC-ND

Cite this

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abstract = "Older people are susceptible to the adverse effects of anticholinergic medications, including cognitive impairment. A systematic review of observational studies reported mixed associations between high anticholinergic burden, a cumulative measure of anticholinergic medications, and cognitive performance in older people. Observational studies may have biased estimates of the impact of exposures, as the exposed and unexposed may systematically differ in covariates associated with the outcomes.",

author = "Prasad Nishtala and Heather Allore and Ling Han and Hamish Jamieson and Hilmer, \{Sarah N.\} and Te-Yuan Chyou",

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AU - Nishtala, Prasad

AU - Allore, Heather

AU - Han, Ling

AU - Jamieson, Hamish

AU - Hilmer, Sarah N.

AU - Chyou, Te-Yuan

PY - 2020/9

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N2 - Older people are susceptible to the adverse effects of anticholinergic medications, including cognitive impairment. A systematic review of observational studies reported mixed associations between high anticholinergic burden, a cumulative measure of anticholinergic medications, and cognitive performance in older people. Observational studies may have biased estimates of the impact of exposures, as the exposed and unexposed may systematically differ in covariates associated with the outcomes.

AB - Older people are susceptible to the adverse effects of anticholinergic medications, including cognitive impairment. A systematic review of observational studies reported mixed associations between high anticholinergic burden, a cumulative measure of anticholinergic medications, and cognitive performance in older people. Observational studies may have biased estimates of the impact of exposures, as the exposed and unexposed may systematically differ in covariates associated with the outcomes.

UR - https://www.scopus.com/pages/publications/85085304657

U2 - 10.1016/j.jamda.2020.03.027

DO - 10.1016/j.jamda.2020.03.027

M3 - Letter

SN - 1525-8610

VL - 21

SP - 1357-1358.e3

JO - Journal of the American Medical Directors Association

JF - Journal of the American Medical Directors Association

IS - 9

ER -

Impact of Anticholinergic Burden on Cognitive Performance: A Cohort Study of Community-Dwelling Older Adults

Abstract

UN SDGs

ASJC Scopus subject areas

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