Imaging drug delivery to skin with coherent raman scattering microscopy

Natalie A. Belsey, Luis Rodrigo Contreras-Rojas, Richard H. Guy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Coherent Raman scattering microscopy is a new technique allowing high-resolution 3D imaging of the skin, with chemical contrast obtained based on Raman scattering. This technique is label-free and, unlike conventional microscopy techniques, does not rely on fluorescent probes, which are not good models for drug substances because of their different physicochemical properties and dissimilar skin penetration kinetics. Unlike other techniques such as tape stripping, coherent Raman scattering microscopy is non-destructive. The penetration pathway(s) of the drug and excipients from a topical vehicle can be visualised independently, and the ‘metamorphosis’ of an applied formulation at the surface of the skin can be imaged in real time.

Original languageEnglish
Title of host publicationNon Invasive Diagnostic Techniques in Clinical Dermatology
PublisherSpringer Berlin Heidelberg
Pages225-231
Number of pages7
ISBN (Electronic)9783642321092
ISBN (Print)9783642321085
DOIs
Publication statusPublished - 1 Jan 2014

ASJC Scopus subject areas

  • Medicine(all)

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