hif-1 plays a role in hypoxia-induced gustatory plasticity of Caenorhabditis elegans

Nabila Sorathia, Neha Chawda, Konstantina Saraki, Medha S. Rajadhyaksha, Momna Hejmadi

Research output: Contribution to journalArticle

Abstract

Background: Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of low oxygen levels, inducing expression of genes involved in mediating the response to hypoxia to maintain cellular oxygen homeostasis. Caenorhabditis elegans is a soil nematode that has evolved specialized chemosensory neurons that detect changes in oxygen levels and guide its behaviour and responses to food. The role of the hif-1 gene in modifying chemosensory behaviour in response to chemical hypoxia however remains unclear. Furthermore, the role of epigenetic modifiers in mediating this behavioural response to hypoxia is unclear. Aims: Our study addresses two questions (a) Do hypoxia-mimetics modify worm behaviour and (b) Are these behaviours modulated by HIF-dependent expression of epigenetic regulators? Material and methods: This study used established behavioural paradigms in hif-1 mutant strains of C. elegans, to study responses to chemical hypoxia. Results: We show that exposure to the hypoxia-mimetic, sodium sulphite, changes the gustatory responses, chemotaxis, gustatory plasticity and associative conditioning behaviour. Longer-term exposure to hypoxia changes the behavioural response of wild type C. elegans, mediated by the HIF pathway. Epigenetic modifiers, lithium chloride and valproic acid, further modulate these behavioural responses.

LanguageEnglish
JournalInternational Journal of Neuroscience
Early online date20 Mar 2019
DOIs
StatusE-pub ahead of print - 20 Mar 2019

Keywords

  • behaviour
  • Caenorhabditis elegans
  • epigenetic
  • Hypoxia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

hif-1 plays a role in hypoxia-induced gustatory plasticity of Caenorhabditis elegans. / Sorathia, Nabila; Chawda, Neha; Saraki, Konstantina; Rajadhyaksha, Medha S.; Hejmadi, Momna.

In: International Journal of Neuroscience, 20.03.2019.

Research output: Contribution to journalArticle

Sorathia, Nabila ; Chawda, Neha ; Saraki, Konstantina ; Rajadhyaksha, Medha S. ; Hejmadi, Momna. / hif-1 plays a role in hypoxia-induced gustatory plasticity of Caenorhabditis elegans. In: International Journal of Neuroscience. 2019.
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