Igf2 imprinting in development and disease

Wolf Reik, Miguel Constancia, Wendy Dean, Karen Davies, Lucy Bowden, Adele Murrell, Robert Feil, Joern Walter, Gavin Kelsey

Research output: Contribution to journalArticlepeer-review

74 Citations (SciVal)

Abstract

Igf2 is one of the first imprinted genes discovered and occupies a centre stage in the study of imprinting. This is because it has dramatic effects on the control of fetal growth, it is involved in growth disorders and in cancer, it interacts with products of other imprinted genes, and its imprinting status is under complex regulation in a cluster of tightly linked imprinted genes. Here we review briefly the key features of Igf2 imprinting in normal development and in disease, and hope to show what a fascinating subject of study this gene and its biology provides.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalInternational Journal of Developmental Biology
Volume44
Issue number1
Publication statusPublished - 31 Dec 2000

Keywords

  • DNA methylation
  • Fetal growth
  • Genetic disease
  • Imprinting
  • Mouse development

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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