IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4

Iain MacArthur; Paul B Mann; Eric T Harvill; Andrew Preston

doi:10.1177/0968051907082609

IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4

Iain MacArthur, Paul B Mann, Eric T Harvill, Andrew Preston

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (SciVal)

Abstract

The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

Original language	English
Pages (from-to)	243-247
Number of pages	5
Journal	Journal of Endotoxin Research
Volume	13
Issue number	4
DOIs	https://doi.org/10.1177/0968051907082609
Publication status	Published - 2007

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title = "IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4",

abstract = "The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.",

author = "Iain MacArthur and Mann, {Paul B} and Harvill, {Eric T} and Andrew Preston",

year = "2007",

doi = "10.1177/0968051907082609",

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journal = "Journal of Endotoxin Research",

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AU - Mann, Paul B

AU - Harvill, Eric T

AU - Preston, Andrew

PY - 2007

Y1 - 2007

N2 - The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

AB - The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

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DO - 10.1177/0968051907082609

M3 - Article

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JO - Journal of Endotoxin Research

JF - Journal of Endotoxin Research

IS - 4

ER -

IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4

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