Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice

ME Haywood; MB Hogarth; JH Slingsby; SJ Rose; PJ Allen; EM Thompson; MA Maibaum; P Chandler; KA Davies; E Simpson; MJ Walport; Bernard J Morley

doi:10.1002/1529-0131(200002)43:2<349::AID-ANR14>3.0.CO;2-M

Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice

ME Haywood, MB Hogarth, JH Slingsby, SJ Rose, PJ Allen, EM Thompson, MA Maibaum, P Chandler, KA Davies, E Simpson, MJ Walport, Bernard J Morley

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Abstract

OBJECTIVE: To identify intervals containing systemic lupus erythematosus (SLE) susceptibility alleles in the BXSB strain of mice. METHODS: We analyzed 286 (B10 x [B10 x BXSB]F1) backcross mice for a range of phenotypic traits associated with the development of SLE in BXSB mice. The mice were genotyped using 93 microsatellite markers, and the linkage of these markers to disease was studied by extreme-phenotype and quantitative trait locus analysis. RESULTS: The disease phenotype in these backcross mice was less severe than that in BXSB mice. However, antinuclear antibody production was increased compared with the parental strain. We identified 4 areas of genetic linkage to disease on chromosome 1 (Bxs1-4), 1 on chromosome 3 (Bxs5), and another interval on chromosome 13 which were associated with various aspects of the phenotype. Bxs4 and Bxs5 are located in regions not previously linked to disease in other models of SLE. CONCLUSION: SLE in the BXSB mouse model has a complex genetic basis and involves at least 5 distinct intervals located on chromosomes 1 and 3. There is evidence that different intervals affect particular aspects of the SLE phenotype.

Original language	English
Pages (from-to)	349-355
Number of pages	7
Journal	Arthritis & Rheumatism
Volume	43
Issue number	2
DOIs	https://doi.org/10.1002/1529-0131(200002)43:2<349::AID-ANR14>3.0.CO;2-M
Publication status	Published - Feb 2000

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Haywood, ME., Hogarth, MB., Slingsby, JH., Rose, SJ., Allen, PJ., Thompson, EM., Maibaum, MA., Chandler, P., Davies, KA., Simpson, E., Walport, MJ., & Morley, B. J. (2000). Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice. Arthritis & Rheumatism, 43(2), 349-355. https://doi.org/10.1002/1529-0131(200002)43:2<349::AID-ANR14>3.0.CO;2-M

Haywood, ME, Hogarth, MB, Slingsby, JH, Rose, SJ, Allen, PJ, Thompson, EM, Maibaum, MA, Chandler, P, Davies, KA, Simpson, E, Walport, MJ & Morley, BJ 2000, 'Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice', Arthritis & Rheumatism, vol. 43, no. 2, pp. 349-355. https://doi.org/10.1002/1529-0131(200002)43:2<349::AID-ANR14>3.0.CO;2-M

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title = "Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice",

abstract = "OBJECTIVE: To identify intervals containing systemic lupus erythematosus (SLE) susceptibility alleles in the BXSB strain of mice. METHODS: We analyzed 286 (B10 x [B10 x BXSB]F1) backcross mice for a range of phenotypic traits associated with the development of SLE in BXSB mice. The mice were genotyped using 93 microsatellite markers, and the linkage of these markers to disease was studied by extreme-phenotype and quantitative trait locus analysis. RESULTS: The disease phenotype in these backcross mice was less severe than that in BXSB mice. However, antinuclear antibody production was increased compared with the parental strain. We identified 4 areas of genetic linkage to disease on chromosome 1 (Bxs1-4), 1 on chromosome 3 (Bxs5), and another interval on chromosome 13 which were associated with various aspects of the phenotype. Bxs4 and Bxs5 are located in regions not previously linked to disease in other models of SLE. CONCLUSION: SLE in the BXSB mouse model has a complex genetic basis and involves at least 5 distinct intervals located on chromosomes 1 and 3. There is evidence that different intervals affect particular aspects of the SLE phenotype.",

author = "ME Haywood and MB Hogarth and JH Slingsby and SJ Rose and PJ Allen and EM Thompson and MA Maibaum and P Chandler and KA Davies and E Simpson and MJ Walport and Morley, {Bernard J}",

year = "2000",

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doi = "10.1002/1529-0131(200002)43:2<349::AID-ANR14>3.0.CO;2-M",

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T1 - Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice

AU - Haywood, ME

AU - Hogarth, MB

AU - Slingsby, JH

AU - Rose, SJ

AU - Allen, PJ

AU - Thompson, EM

AU - Maibaum, MA

AU - Chandler, P

AU - Davies, KA

AU - Simpson, E

AU - Walport, MJ

AU - Morley, Bernard J

PY - 2000/2

Y1 - 2000/2

N2 - OBJECTIVE: To identify intervals containing systemic lupus erythematosus (SLE) susceptibility alleles in the BXSB strain of mice. METHODS: We analyzed 286 (B10 x [B10 x BXSB]F1) backcross mice for a range of phenotypic traits associated with the development of SLE in BXSB mice. The mice were genotyped using 93 microsatellite markers, and the linkage of these markers to disease was studied by extreme-phenotype and quantitative trait locus analysis. RESULTS: The disease phenotype in these backcross mice was less severe than that in BXSB mice. However, antinuclear antibody production was increased compared with the parental strain. We identified 4 areas of genetic linkage to disease on chromosome 1 (Bxs1-4), 1 on chromosome 3 (Bxs5), and another interval on chromosome 13 which were associated with various aspects of the phenotype. Bxs4 and Bxs5 are located in regions not previously linked to disease in other models of SLE. CONCLUSION: SLE in the BXSB mouse model has a complex genetic basis and involves at least 5 distinct intervals located on chromosomes 1 and 3. There is evidence that different intervals affect particular aspects of the SLE phenotype.

AB - OBJECTIVE: To identify intervals containing systemic lupus erythematosus (SLE) susceptibility alleles in the BXSB strain of mice. METHODS: We analyzed 286 (B10 x [B10 x BXSB]F1) backcross mice for a range of phenotypic traits associated with the development of SLE in BXSB mice. The mice were genotyped using 93 microsatellite markers, and the linkage of these markers to disease was studied by extreme-phenotype and quantitative trait locus analysis. RESULTS: The disease phenotype in these backcross mice was less severe than that in BXSB mice. However, antinuclear antibody production was increased compared with the parental strain. We identified 4 areas of genetic linkage to disease on chromosome 1 (Bxs1-4), 1 on chromosome 3 (Bxs5), and another interval on chromosome 13 which were associated with various aspects of the phenotype. Bxs4 and Bxs5 are located in regions not previously linked to disease in other models of SLE. CONCLUSION: SLE in the BXSB mouse model has a complex genetic basis and involves at least 5 distinct intervals located on chromosomes 1 and 3. There is evidence that different intervals affect particular aspects of the SLE phenotype.

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U2 - 10.1002/1529-0131(200002)43:2<349::AID-ANR14>3.0.CO;2-M

DO - 10.1002/1529-0131(200002)43:2<349::AID-ANR14>3.0.CO;2-M

M3 - Article

SN - 0004-3591

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SP - 349

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JO - Arthritis & Rheumatism

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ER -

Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice

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