Identification of connective tissue disease autoantibodies and a novel autoantibody anti-annexin A11 in patients with “idiopathic” interstitial lung disease

Sarah Tansley, Fionnuala McMorrow, Caroline Cotton, Huzaifa I. Adamali, Shaney L Barratt, Zoe Betteridge, Janire Perurena-Prieto, Michael A. Gibbons, Raman Kular, Aravinthan Loganathan, Janine A Lamb, Hui Lu, Robert P. New, Diane Pratt, Pilar Rivera-Ortega, Ross Sayers, Matthew Steward, Lachlan Stranks, Edward M Vital, Lisa SpencerNeil McHugh, Robert G Cooper

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Autoantibodies are a hallmark feature of Connective Tissue Diseases (CTD). Their presence in patients with idiopathic interstitial lung disease (ILD) may suggest covert CTD. We aimed to determine the prevalence of CTD autoantibodies in patients diagnosed with idiopathic ILD.

Methods: 499 patient sera were analysed: 251 idiopathic pulmonary fibrosis (IPF), 206 idiopathic non-specific interstitial pneumonia (iNSIP) and 42 cryptogenic organising pneumonia (COP). Autoantibody status was determined by immunoprecipitation.

Results: 2.4% of IPF sera had a CTD-autoantibody compared to 10.2% of iNSIP and 7.3% of COP. 45% of autoantibodies were anti-synthetases. A novel autoantibody targeting an unknown 56 kDa protein was found in seven IPF patients (2.8%) and two NSIP (1%) patients. This was characterised as anti-annexin A11.

Conclusion: Specific guidance on autoantibody testing and interpretation in patients with ILD could improve diagnostic accuracy. Further work is required to determine the clinical significance of anti-annexin A11.
Original languageEnglish
Article number110201
JournalClinical Immunology
Volume262
Early online date2 Apr 2024
DOIs
Publication statusE-pub ahead of print - 2 Apr 2024

Data Availability Statement

All data can be made available on application to the UK-BILD steering committee.

Keywords

  • Autoantibody
  • Connective tissue disease
  • Diagnostic assay
  • Interstitial lung disease
  • Myositis
  • Systemic sclerosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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