Aza-conjugate addition methodology for the synthesis of N-hydroxy-isoindolin-1-ones

Santiago Royo, Robert S L Chapman, Alisia M. Sim, Lucy R. Peacock, Steven D. Bull

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aryl-aldehydes containing ortho-substituted propiolate fragments react with hydroxylamine to afford carbinolamine intermediates that undergo intramolecular aza-conjugate addition reactions to afford N-hydroxy-2.3-dihydro-isoindolin-1-ones that can be reduced to their corresponding isoindolin-1-ones and isoindoles.

Original languageEnglish
Pages (from-to)1146-1149
Number of pages4
JournalOrganic Letters
Volume18
Issue number5
Early online date22 Feb 2016
DOIs
Publication statusPublished - 4 Mar 2016

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