Aza-conjugate addition methodology for the synthesis of N-hydroxy-isoindolin-1-ones

Santiago Royo, Robert S L Chapman, Alisia M. Sim, Lucy R. Peacock, Steven D. Bull

Research output: Contribution to journalArticlepeer-review

21 Citations (SciVal)


Aryl-aldehydes containing ortho-substituted propiolate fragments react with hydroxylamine to afford carbinolamine intermediates that undergo intramolecular aza-conjugate addition reactions to afford N-hydroxy-2.3-dihydro-isoindolin-1-ones that can be reduced to their corresponding isoindolin-1-ones and isoindoles.

Original languageEnglish
Pages (from-to)1146-1149
Number of pages4
JournalOrganic Letters
Issue number5
Early online date22 Feb 2016
Publication statusPublished - 4 Mar 2016


Dive into the research topics of 'Aza-conjugate addition methodology for the synthesis of N-hydroxy-isoindolin-1-ones'. Together they form a unique fingerprint.

Cite this