Hydroxyapatite nanoparticles formed under a wet mechanochemical method

Nudthakarn Kosachan, Angkhana Jaroenworaluck, Sirithan Jiemsirilers, Supatra Jinawath, Ron Stevens

Research output: Contribution to journalArticlepeer-review

12 Citations (SciVal)


Hydroxyapatite (HA) nanoparticles were synthesized using a wet mechanochemical method without a calcination process. Dicalcium phosphate dihydrate (CaHPO4·2H2O) and calcium carbonate (CaCO3) were mixed and milled in a planary mill using ethanol or water as liquid media in the two different synthesized routes. Effects of rotation speed and milling time on the final products formed have been studied. Experimental results showed that HA phase having a characteristic of low crystallinity could be formed under the synthesis route using water. The original phases of both starting chemicals were remained without HA formation in the synthesis route using ethanol. Particle size and morphology of HA nanoparticles were obviously depended on optimum conditions of rotation speed and milling time. Differences on phase formation in both synthesized routes have been considered and discussed based on occurring chemical reaction possibilities.

Original languageEnglish
Pages (from-to)679-688
Number of pages10
JournalJournal of Biomedical Materials Research Part B-Applied Biomaterials
Issue number3
Publication statusPublished - 1 Apr 2017


  • calcium carbonate (CaCO3)
  • dicalcium phosphate dihydrate (CaHPO4-2H2O)
  • hydroxyapatite
  • nanoparticles
  • wet mechanochemical method

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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