Hydrothermal conversion of one-photon-fluorescent poly-(4-vinylpyridine) into two-photon-fluorescent carbon nanodots

Katherine Lawrence; Fengjie Xia; Rory L Arrowsmith; Haobo Ge; Geoffrey W Nelson; John S Foord; Monica Felipe-Sotelo; Nick D M Evans; John M. Mitchels; Stephen E Flower; Stanley W Botchway; Daniel Wolverson; Gazi Aliev; Tony D James; Sofia I. Pascu; Frank Marken

doi:10.1021/la404866s

Hydrothermal conversion of one-photon-fluorescent poly-(4-vinylpyridine) into two-photon-fluorescent carbon nanodots

Katherine Lawrence, Fengjie Xia, Rory L Arrowsmith, Haobo Ge, Geoffrey W Nelson, John S Foord, Monica Felipe-Sotelo, Nick D M Evans, John M. Mitchels, Stephen E Flower, Stanley W Botchway, Daniel Wolverson, Gazi Aliev, Tony D James, Sofia I. Pascu, Frank Marken

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Abstract

A novel two-photon-fluorescent N,O-heteroatom-rich carbon nanomaterial has been synthesized and characterized. The new carbon nanoparticles were produced by hydro-thermal conversion from a one-photon-fluorescent poly-(4-vinylpyridine) precursor (P4VP). The carbonized particles (cP4VP-dots) with non-uniform particle diameter (ranging from sub-6 nm to 20 nm with some aggregates up to 200 nm) exhibit strong fluorescent properties in different solvents and have also been investigated for applications in cell culture media. The cP4VP-dots retain their intrinsic fluorescence in a cellular environment and exhibit an average excited state lifetime of 2.0 ± 0.9 ns in cell. The cP4VP-dots enter HeLa cells and do not cause significant damage to outer cell membranes. They provide one-photon or two-photon fluorescent synthetic scaffolds for imaging applications and/or drug delivery.

Original language	English
Pages (from-to)	11746–11752
Journal	Langmuir
Volume	30
Issue number	39
Early online date	12 Mar 2014
DOIs	https://doi.org/10.1021/la404866s
Publication status	Published - 7 Oct 2014

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10.1021/la404866s

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Lawrence, K., Xia, F., Arrowsmith, R. L., Ge, H., Nelson, G. W., Foord, J. S., Felipe-Sotelo, M., Evans, N. D. M., Mitchels, J. M., Flower, S. E., Botchway, S. W., Wolverson, D., Aliev, G., James, T. D., Pascu, S. I., & Marken, F. (2014). Hydrothermal conversion of one-photon-fluorescent poly-(4-vinylpyridine) into two-photon-fluorescent carbon nanodots. Langmuir , 30(39), 11746–11752. https://doi.org/10.1021/la404866s

Lawrence, K, Xia, F, Arrowsmith, RL, Ge, H, Nelson, GW, Foord, JS, Felipe-Sotelo, M, Evans, NDM, Mitchels, JM, Flower, SE, Botchway, SW, Wolverson, D, Aliev, G, James, TD , Pascu, SI & Marken, F 2014, 'Hydrothermal conversion of one-photon-fluorescent poly-(4-vinylpyridine) into two-photon-fluorescent carbon nanodots', Langmuir , vol. 30, no. 39, pp. 11746–11752. https://doi.org/10.1021/la404866s

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title = "Hydrothermal conversion of one-photon-fluorescent poly-(4-vinylpyridine) into two-photon-fluorescent carbon nanodots",

abstract = "A novel two-photon-fluorescent N,O-heteroatom-rich carbon nanomaterial has been synthesized and characterized. The new carbon nanoparticles were produced by hydro-thermal conversion from a one-photon-fluorescent poly-(4-vinylpyridine) precursor (P4VP). The carbonized particles (cP4VP-dots) with non-uniform particle diameter (ranging from sub-6 nm to 20 nm with some aggregates up to 200 nm) exhibit strong fluorescent properties in different solvents and have also been investigated for applications in cell culture media. The cP4VP-dots retain their intrinsic fluorescence in a cellular environment and exhibit an average excited state lifetime of 2.0 ± 0.9 ns in cell. The cP4VP-dots enter HeLa cells and do not cause significant damage to outer cell membranes. They provide one-photon or two-photon fluorescent synthetic scaffolds for imaging applications and/or drug delivery.",

author = "Katherine Lawrence and Fengjie Xia and Arrowsmith, {Rory L} and Haobo Ge and Nelson, {Geoffrey W} and Foord, {John S} and Monica Felipe-Sotelo and Evans, {Nick D M} and Mitchels, {John M.} and Flower, {Stephen E} and Botchway, {Stanley W} and Daniel Wolverson and Gazi Aliev and James, {Tony D} and Pascu, {Sofia I.} and Frank Marken",

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AU - Nelson, Geoffrey W

AU - Foord, John S

AU - Felipe-Sotelo, Monica

AU - Evans, Nick D M

AU - Mitchels, John M.

AU - Flower, Stephen E

AU - Botchway, Stanley W

AU - Wolverson, Daniel

AU - Aliev, Gazi

AU - James, Tony D

AU - Pascu, Sofia I.

AU - Marken, Frank

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AB - A novel two-photon-fluorescent N,O-heteroatom-rich carbon nanomaterial has been synthesized and characterized. The new carbon nanoparticles were produced by hydro-thermal conversion from a one-photon-fluorescent poly-(4-vinylpyridine) precursor (P4VP). The carbonized particles (cP4VP-dots) with non-uniform particle diameter (ranging from sub-6 nm to 20 nm with some aggregates up to 200 nm) exhibit strong fluorescent properties in different solvents and have also been investigated for applications in cell culture media. The cP4VP-dots retain their intrinsic fluorescence in a cellular environment and exhibit an average excited state lifetime of 2.0 ± 0.9 ns in cell. The cP4VP-dots enter HeLa cells and do not cause significant damage to outer cell membranes. They provide one-photon or two-photon fluorescent synthetic scaffolds for imaging applications and/or drug delivery.

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JO - Langmuir

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Hydrothermal conversion of one-photon-fluorescent poly-(4-vinylpyridine) into two-photon-fluorescent carbon nanodots

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Fluorescence Lifetime Imaging of New Functional Biomaterials Invasive Early Tumour Diagnosis

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Hydrothermal conversion of one-photon-fluorescent poly-(4-vinylpyridine) into two-photon-fluorescent carbon nanodots

Abstract

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Fluorescence Lifetime Imaging of New Functional Biomaterials Invasive Early Tumour Diagnosis

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