Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades

E Kiss-Toth; S M Bagstaff; H Y Sung; V Jozsa; C Dempsey; J Christopher Caunt; K M Oxley; D H Wyllie; T Polgar; M Harte; L A J O'Neill; E E Qwarnstrom; S K Dower

doi:10.1074/jbc.M407732200

Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades

E Kiss-Toth, S M Bagstaff, H Y Sung, V Jozsa, C Dempsey, J Christopher Caunt, K M Oxley, D H Wyllie, T Polgar, M Harte, L A J O'Neill, E E Qwarnstrom, S K Dower

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

259 Citations (SciVal)

Abstract

Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with Trbs and regulate their steady state levels. Further, Trbs selectively regulate the activation of extracellular signal-regulated kinases, c-Jun NH2-terminal kinases, and p38 MAPK with different relative levels of activity for the three classes of MAPK observed depending on the level of Trb expression. These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK.

Original language	English
Pages (from-to)	42703-42708
Number of pages	6
Journal	Journal of Biological Chemistry
Volume	279
Issue number	41
DOIs	https://doi.org/10.1074/jbc.M407732200
Publication status	Published - 2004

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Kiss-Toth, E., Bagstaff, S. M., Sung, H. Y., Jozsa, V., Dempsey, C., Caunt, J. C., Oxley, K. M., Wyllie, D. H., Polgar, T., Harte, M., O'Neill, L. A. J., Qwarnstrom, E. E., & Dower, S. K. (2004). Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades. Journal of Biological Chemistry, 279(41), 42703-42708. https://doi.org/10.1074/jbc.M407732200

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title = "Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades",

abstract = "Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with Trbs and regulate their steady state levels. Further, Trbs selectively regulate the activation of extracellular signal-regulated kinases, c-Jun NH2-terminal kinases, and p38 MAPK with different relative levels of activity for the three classes of MAPK observed depending on the level of Trb expression. These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK.",

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year = "2004",

doi = "10.1074/jbc.M407732200",

language = "English",

volume = "279",

pages = "42703--42708",

journal = "Journal of Biological Chemistry",

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TY - JOUR

T1 - Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades

AU - Kiss-Toth, E

AU - Bagstaff, S M

AU - Sung, H Y

AU - Jozsa, V

AU - Dempsey, C

AU - Caunt, J Christopher

AU - Oxley, K M

AU - Wyllie, D H

AU - Polgar, T

AU - Harte, M

AU - O'Neill, L A J

AU - Qwarnstrom, E E

AU - Dower, S K

PY - 2004

Y1 - 2004

N2 - Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with Trbs and regulate their steady state levels. Further, Trbs selectively regulate the activation of extracellular signal-regulated kinases, c-Jun NH2-terminal kinases, and p38 MAPK with different relative levels of activity for the three classes of MAPK observed depending on the level of Trb expression. These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK.

AB - Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with Trbs and regulate their steady state levels. Further, Trbs selectively regulate the activation of extracellular signal-regulated kinases, c-Jun NH2-terminal kinases, and p38 MAPK with different relative levels of activity for the three classes of MAPK observed depending on the level of Trb expression. These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK.

UR - http://dx.doi.org/10.1074/jbc.M407732200

U2 - 10.1074/jbc.M407732200

DO - 10.1074/jbc.M407732200

M3 - Article

SN - 0021-9258

VL - 279

SP - 42703

EP - 42708

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 41

ER -

Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades

Abstract

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