Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades

E Kiss-Toth, S M Bagstaff, H Y Sung, V Jozsa, C Dempsey, J Christopher Caunt, K M Oxley, D H Wyllie, T Polgar, M Harte, L A J O'Neill, E E Qwarnstrom, S K Dower

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256 Citations (SciVal)


Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with Trbs and regulate their steady state levels. Further, Trbs selectively regulate the activation of extracellular signal-regulated kinases, c-Jun NH2-terminal kinases, and p38 MAPK with different relative levels of activity for the three classes of MAPK observed depending on the level of Trb expression. These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK.
Original languageEnglish
Pages (from-to)42703-42708
Number of pages6
JournalJournal of Biological Chemistry
Issue number41
Publication statusPublished - 2004


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