Human leukocyte antigen class II associations with systemic sclerosis in South Africans

M Tikly, A Rands, N McHugh, P Wordsworth, K Welsh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Human leukocyte antigen class II typing, using polymerase chain reaction-sequence-specific primers, was performed in 52 Black South Africans with systemic sclerosis (SSc) and 112 controls. Increased frequencies of DR2 in the overall SSc group (OR = 2.4), DRB1*0301 in the limited cutaneous SSc (lcSSc) subset (OR = 9.0), and DQB1*0301/4 in the diffuse cutaneous SSc (dcSSc) subset (OR = 9.0) were observed. Pulmonary fibrosis was associated with DRB1*11 and anti-topoisomerase I antibodies were associated with DPB1*1301 and DRB1*15. Patients with anti-fibrillarin antibodies (AFAs) had increased the frequencies of DRB1*1101 allele group (OR = 16) and DQB1*0603/14 (OR = 13.6). These findings provide new serological and immunogenetic data on a previously unreported population. The association of AFAs with class II alleles merits further investigation.
Original languageEnglish
Pages (from-to)487-490
Number of pages4
JournalTissue Antigens
Volume63
Issue number5
Early online date22 Apr 2004
DOIs
Publication statusPublished - May 2004

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Systemic Scleroderma
HLA Antigens
Antibodies
Anti-Idiotypic Antibodies
Alleles
Diffuse Scleroderma
Immunogenetics
Type I DNA Topoisomerase
Pulmonary Fibrosis
Immunoglobulin Isotypes
Polymerase chain reaction
Polymerase Chain Reaction
Skin
Population
fibrillarin

Cite this

Human leukocyte antigen class II associations with systemic sclerosis in South Africans. / Tikly, M; Rands, A; McHugh, N; Wordsworth, P; Welsh, K.

In: Tissue Antigens, Vol. 63, No. 5, 05.2004, p. 487-490.

Research output: Contribution to journalArticle

Tikly, M ; Rands, A ; McHugh, N ; Wordsworth, P ; Welsh, K. / Human leukocyte antigen class II associations with systemic sclerosis in South Africans. In: Tissue Antigens. 2004 ; Vol. 63, No. 5. pp. 487-490.
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