Human leukocyte antigen class II associations with systemic sclerosis in South Africans

M Tikly, A Rands, N McHugh, P Wordsworth, K Welsh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Human leukocyte antigen class II typing, using polymerase chain reaction-sequence-specific primers, was performed in 52 Black South Africans with systemic sclerosis (SSc) and 112 controls. Increased frequencies of DR2 in the overall SSc group (OR = 2.4), DRB1*0301 in the limited cutaneous SSc (lcSSc) subset (OR = 9.0), and DQB1*0301/4 in the diffuse cutaneous SSc (dcSSc) subset (OR = 9.0) were observed. Pulmonary fibrosis was associated with DRB1*11 and anti-topoisomerase I antibodies were associated with DPB1*1301 and DRB1*15. Patients with anti-fibrillarin antibodies (AFAs) had increased the frequencies of DRB1*1101 allele group (OR = 16) and DQB1*0603/14 (OR = 13.6). These findings provide new serological and immunogenetic data on a previously unreported population. The association of AFAs with class II alleles merits further investigation.
Original languageEnglish
Pages (from-to)487-490
Number of pages4
JournalTissue Antigens
Volume63
Issue number5
Early online date22 Apr 2004
DOIs
Publication statusPublished - May 2004

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