Human antisense genes have unusually short introns: evidence for selection for rapid transcription

J J Chen; M Sun; L D Hurst; G G Carmichael; J D Rowley

doi:10.1016/j.tig.2005.02.003

Human antisense genes have unusually short introns: evidence for selection for rapid transcription

J J Chen
, M Sun
, L D Hurst
, G G Carmichael
, J D Rowley

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

55 Citations (SciVal)

Abstract

We suggest that small introns are favored in genes requiring a minimal response time ('nimble' genes), and that antisense genes might be prime candidates for such nimble genes. In this article, we show that antisense genes have significantly shorter introns than all other gene categories, which supports our proposal that the short introns of antisense genes might be functionally important and integrally related to their potential role in efficient gene regulation.

Original language	English
Pages (from-to)	203-207
Number of pages	5
Journal	Trends in Genetics
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.tig.2005.02.003
Publication status	Published - 2005

Bibliographical note

ID number: ISI:000228286300003

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10.1016/j.tig.2005.02.003

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title = "Human antisense genes have unusually short introns: evidence for selection for rapid transcription",

abstract = "We suggest that small introns are favored in genes requiring a minimal response time ('nimble' genes), and that antisense genes might be prime candidates for such nimble genes. In this article, we show that antisense genes have significantly shorter introns than all other gene categories, which supports our proposal that the short introns of antisense genes might be functionally important and integrally related to their potential role in efficient gene regulation.",

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AU - Chen, J J

AU - Sun, M

AU - Hurst, L D

AU - Carmichael, G G

AU - Rowley, J D

N1 - ID number: ISI:000228286300003

PY - 2005

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N2 - We suggest that small introns are favored in genes requiring a minimal response time ('nimble' genes), and that antisense genes might be prime candidates for such nimble genes. In this article, we show that antisense genes have significantly shorter introns than all other gene categories, which supports our proposal that the short introns of antisense genes might be functionally important and integrally related to their potential role in efficient gene regulation.

AB - We suggest that small introns are favored in genes requiring a minimal response time ('nimble' genes), and that antisense genes might be prime candidates for such nimble genes. In this article, we show that antisense genes have significantly shorter introns than all other gene categories, which supports our proposal that the short introns of antisense genes might be functionally important and integrally related to their potential role in efficient gene regulation.

U2 - 10.1016/j.tig.2005.02.003

DO - 10.1016/j.tig.2005.02.003

M3 - Article

SN - 0168-9525

VL - 21

SP - 203

EP - 207

JO - Trends in Genetics

JF - Trends in Genetics

IS - 4

ER -

Human antisense genes have unusually short introns: evidence for selection for rapid transcription

Abstract

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