How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency

Christine Römer; Manvendra Singh; Laurence D. Hurst; Zsuzsanna Izsvák

doi:10.1016/j.coviro.2017.07.001

How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency

Christine Römer, Manvendra Singh, Laurence D. Hurst, Zsuzsanna Izsvák

Helmholtz Association

Research output: Contribution to journal › Review article › peer-review

21 Citations (SciVal)

Abstract

HERVH is one of the most successful endogenous retrovirus in the human genome. Relative to other endogenous retroviruses, slower degradation of HERVH internal sequences indicates their potential relevance for the host. HERVH is transcriptionally active during human preimplantation embryogenesis. In this review, we focus on the role of HERVH in regulating human pluripotency. The HERVH-mediated pluripotency network has been evolved recently in primates. Nevertheless, it became an essential feature of human pluripotency. We discuss how HERVH modulates the human pluripotency network by providing alternative transcription factor binding sites, functioning as a long-range enhancer, and as being a major source for pluripotency specific long non-coding RNAs and chimeric transcripts.

Original language	English
Pages (from-to)	49-58
Number of pages	10
Journal	Current Opinion in Virology
Volume	25
Early online date	24 Jul 2017
DOIs	https://doi.org/10.1016/j.coviro.2017.07.001
Publication status	Published - 31 Aug 2017

Bibliographical note

Funding Information:
Z.I. is funded by European Research Council, ERC Advanced [ERC-2011-ADG 294742]. The authors thank Katarina Stevanovic for proof-reading the manuscript.

Publisher Copyright:
© 2017

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

Virology

Access to Document

10.1016/j.coviro.2017.07.001

Cite this

@article{fc4e92169f9549f4a7a944247c29fd8c,

title = "How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency",

abstract = "HERVH is one of the most successful endogenous retrovirus in the human genome. Relative to other endogenous retroviruses, slower degradation of HERVH internal sequences indicates their potential relevance for the host. HERVH is transcriptionally active during human preimplantation embryogenesis. In this review, we focus on the role of HERVH in regulating human pluripotency. The HERVH-mediated pluripotency network has been evolved recently in primates. Nevertheless, it became an essential feature of human pluripotency. We discuss how HERVH modulates the human pluripotency network by providing alternative transcription factor binding sites, functioning as a long-range enhancer, and as being a major source for pluripotency specific long non-coding RNAs and chimeric transcripts.",

author = "Christine R{\"o}mer and Manvendra Singh and Hurst, {Laurence D.} and Zsuzsanna Izsv{\'a}k",

note = "Funding Information: Z.I. is funded by European Research Council, ERC Advanced [ERC-2011-ADG 294742]. The authors thank Katarina Stevanovic for proof-reading the manuscript. Publisher Copyright: {\textcopyright} 2017 Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2017",

month = aug,

day = "31",

doi = "10.1016/j.coviro.2017.07.001",

language = "English",

volume = "25",

pages = "49--58",

journal = "Current Opinion in Virology",

issn = "1879-6257",

publisher = "Elsevier",

}

TY - JOUR

T1 - How to tame an endogenous retrovirus

T2 - HERVH and the evolution of human pluripotency

AU - Römer, Christine

AU - Singh, Manvendra

AU - Hurst, Laurence D.

AU - Izsvák, Zsuzsanna

N1 - Funding Information: Z.I. is funded by European Research Council, ERC Advanced [ERC-2011-ADG 294742]. The authors thank Katarina Stevanovic for proof-reading the manuscript. Publisher Copyright: © 2017 Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2017/8/31

Y1 - 2017/8/31

N2 - HERVH is one of the most successful endogenous retrovirus in the human genome. Relative to other endogenous retroviruses, slower degradation of HERVH internal sequences indicates their potential relevance for the host. HERVH is transcriptionally active during human preimplantation embryogenesis. In this review, we focus on the role of HERVH in regulating human pluripotency. The HERVH-mediated pluripotency network has been evolved recently in primates. Nevertheless, it became an essential feature of human pluripotency. We discuss how HERVH modulates the human pluripotency network by providing alternative transcription factor binding sites, functioning as a long-range enhancer, and as being a major source for pluripotency specific long non-coding RNAs and chimeric transcripts.

AB - HERVH is one of the most successful endogenous retrovirus in the human genome. Relative to other endogenous retroviruses, slower degradation of HERVH internal sequences indicates their potential relevance for the host. HERVH is transcriptionally active during human preimplantation embryogenesis. In this review, we focus on the role of HERVH in regulating human pluripotency. The HERVH-mediated pluripotency network has been evolved recently in primates. Nevertheless, it became an essential feature of human pluripotency. We discuss how HERVH modulates the human pluripotency network by providing alternative transcription factor binding sites, functioning as a long-range enhancer, and as being a major source for pluripotency specific long non-coding RNAs and chimeric transcripts.

UR - http://www.scopus.com/inward/record.url?scp=85025616263&partnerID=8YFLogxK

U2 - 10.1016/j.coviro.2017.07.001

DO - 10.1016/j.coviro.2017.07.001

M3 - Review article

C2 - 28750248

AN - SCOPUS:85025616263

SN - 1879-6257

VL - 25

SP - 49

EP - 58

JO - Current Opinion in Virology

JF - Current Opinion in Virology

ER -

How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this