How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The evolution of Bordetella pertussis from a common ancestor similar to Bordetella bronchiseptica has occurred through large-scale gene loss, inactivation and rearrangements, largely driven by the spread of insertion sequence element repeats throughout the genome. B. pertussis is widely considered to be monomorphic, and recent evolution of the B. pertussis genome appears to, at least in part, be driven by vaccine-based selection. Given the recent global resurgence of whooping cough despite the wide-spread use of vaccination, a more thorough understanding of B. pertussis genomics could be highly informative. In this chapter we discuss the evolution of B. pertussis, including how vaccination is changing the circulating B. pertussis population at the gene-level, and how new sequencing technologies are revealing previously unknown levels of inter- and intra-strain variation at the genome-level.
Original languageEnglish
Title of host publicationPertussis Infection and Vaccines
EditorsG. Fedele, C. Ausiello
PublisherSpringer
Pages1-17
Number of pages17
ISBN (Electronic)978-3-030-33249-5
ISBN (Print)978-3-030-33248-8
DOIs
Publication statusPublished - 19 Jul 2019

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer New York
ISSN (Print)0065-2598

Keywords

  • Bordetella pertussis
  • DNA sequencing
  • Evolution
  • Genomic variation
  • Whooping cough

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ring, N., Abrahams, J., Bagby, S., Preston, A., & MacArthur, I. (2019). How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis. In G. Fedele, & C. Ausiello (Eds.), Pertussis Infection and Vaccines (pp. 1-17). (Advances in Experimental Medicine and Biology). Springer. https://doi.org/10.1007/5584_2019_401