How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis

Research output: Contribution to journalReview article

Abstract

The evolution of Bordetella pertussis from a common ancestor similar to Bordetella bronchiseptica has occurred through large-scale gene loss, inactivation and rearrangements, largely driven by the spread of insertion sequence element repeats throughout the genome. B. pertussis is widely considered to be monomorphic, and recent evolution of the B. pertussis genome appears to, at least in part, be driven by vaccine-based selection. Given the recent global resurgence of whooping cough despite the wide-spread use of vaccination, a more thorough understanding of B. pertussis genomics could be highly informative. In this chapter we discuss the evolution of B. pertussis, including how vaccination is changing the circulating B. pertussis population at the gene-level, and how new sequencing technologies are revealing previously unknown levels of inter- and intra-strain variation at the genome-level.
Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalAdvances in Experimental Medicine and Biology
DOIs
Publication statusPublished - 19 Jul 2019

Keywords

  • Bordetella pertussis
  • DNA sequencing
  • Evolution
  • Genomic variation
  • Whooping cough

Cite this

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title = "How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis",
abstract = "The evolution of Bordetella pertussis from a common ancestor similar to Bordetella bronchiseptica has occurred through large-scale gene loss, inactivation and rearrangements, largely driven by the spread of insertion sequence element repeats throughout the genome. B. pertussis is widely considered to be monomorphic, and recent evolution of the B. pertussis genome appears to, at least in part, be driven by vaccine-based selection. Given the recent global resurgence of whooping cough despite the wide-spread use of vaccination, a more thorough understanding of B. pertussis genomics could be highly informative. In this chapter we discuss the evolution of B. pertussis, including how vaccination is changing the circulating B. pertussis population at the gene-level, and how new sequencing technologies are revealing previously unknown levels of inter- and intra-strain variation at the genome-level.",
keywords = "Bordetella pertussis, DNA sequencing, Evolution, Genomic variation, Whooping cough",
author = "Natalie Ring and Jonathan Abrahams and Stefan Bagby and Andrew Preston and Iain MacArthur",
year = "2019",
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doi = "10.1007/5584_2019_401",
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journal = "Advances in Experimental Medicine and Biology",
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T1 - How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis

AU - Ring, Natalie

AU - Abrahams, Jonathan

AU - Bagby, Stefan

AU - Preston, Andrew

AU - MacArthur, Iain

PY - 2019/7/19

Y1 - 2019/7/19

N2 - The evolution of Bordetella pertussis from a common ancestor similar to Bordetella bronchiseptica has occurred through large-scale gene loss, inactivation and rearrangements, largely driven by the spread of insertion sequence element repeats throughout the genome. B. pertussis is widely considered to be monomorphic, and recent evolution of the B. pertussis genome appears to, at least in part, be driven by vaccine-based selection. Given the recent global resurgence of whooping cough despite the wide-spread use of vaccination, a more thorough understanding of B. pertussis genomics could be highly informative. In this chapter we discuss the evolution of B. pertussis, including how vaccination is changing the circulating B. pertussis population at the gene-level, and how new sequencing technologies are revealing previously unknown levels of inter- and intra-strain variation at the genome-level.

AB - The evolution of Bordetella pertussis from a common ancestor similar to Bordetella bronchiseptica has occurred through large-scale gene loss, inactivation and rearrangements, largely driven by the spread of insertion sequence element repeats throughout the genome. B. pertussis is widely considered to be monomorphic, and recent evolution of the B. pertussis genome appears to, at least in part, be driven by vaccine-based selection. Given the recent global resurgence of whooping cough despite the wide-spread use of vaccination, a more thorough understanding of B. pertussis genomics could be highly informative. In this chapter we discuss the evolution of B. pertussis, including how vaccination is changing the circulating B. pertussis population at the gene-level, and how new sequencing technologies are revealing previously unknown levels of inter- and intra-strain variation at the genome-level.

KW - Bordetella pertussis

KW - DNA sequencing

KW - Evolution

KW - Genomic variation

KW - Whooping cough

U2 - 10.1007/5584_2019_401

DO - 10.1007/5584_2019_401

M3 - Review article

SP - 1

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JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

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