How Does p73 Cause Neuronal Defects?

Maria Victoria Niklison-Chirou, Richard Killick, Richard A. Knight, Pierluigi Nicotera, Gerry Melino, Massimiliano Agostini

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The p53-family member, p73, plays a key role in the development of the central nervous system (CNS), in senescence, and in tumor formation. The role of p73 in neuronal differentiation is complex and involves several downstream pathways. Indeed, in the last few years, we have learnt that TAp73 directly or indirectly regulates several genes involved in neural biology. In particular, TAp73 is involved in the maintenance of neural stem/progenitor cell self-renewal and differentiation throughout the regulation of SOX-2, Hey-2, TRIM32 and Notch. In addition, TAp73 is also implicated in the regulation of the differentiation and function of postmitotic neurons by regulating the expression of p75NTR and GLS2 (glutamine metabolism). Further still, the regulation of miR-34a by TAp73 indicates that microRNAs can also participate in this multifunctional role of p73 in adult brain physiology. However, contradictory results still exist in the relationship between p73 and brain disorders, and this remains an important area for further investigation.

Original languageEnglish
Pages (from-to)4509-4520
Number of pages12
JournalMolecular Neurobiology
Volume53
Issue number7
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • GLS2
  • miR-34
  • Neurodegeneration
  • Neuronal differentiation
  • p73, p75NTR

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Niklison-Chirou, M. V., Killick, R., Knight, R. A., Nicotera, P., Melino, G., & Agostini, M. (2016). How Does p73 Cause Neuronal Defects? Molecular Neurobiology, 53(7), 4509-4520. https://doi.org/10.1007/s12035-015-9381-1