Abstract
The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The findings were mixed, although CBD was found to reduce the effects of THC in several studies. Some studies found that CBD reduced intense experiences of anxiety or psychosis-like effects of THC and blunted some of the impairments on emotion and reward processing. However, CBD did not consistently influence the effects of THC across all studies and outcomes. There was considerable heterogeneity in dose, route of administration and THC:CBD ratio across studies and no clear dose-response profile emerged. Although findings were mixed, this review suggests that CBD may interact with some acute effects of THC.
| Original language | English |
|---|---|
| Pages (from-to) | 696-712 |
| Number of pages | 17 |
| Journal | Neuroscience and Biobehavioral Reviews |
| Volume | 107 |
| Early online date | 30 Sep 2019 |
| DOIs | |
| Publication status | Published - 1 Dec 2019 |
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Cognitive Neuroscience
- Behavioral Neuroscience
Cite this
How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review. / Freeman, Abigail M.; Petrilli, Katherine; Lees, Rachel; Hindocha, Chandni; Mokrysz, Claire; Curran, H. Valerie; Saunders, Rob; Freeman, Tom P.
In: Neuroscience and Biobehavioral Reviews, Vol. 107, 01.12.2019, p. 696-712.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review
AU - Freeman, Abigail M.
AU - Petrilli, Katherine
AU - Lees, Rachel
AU - Hindocha, Chandni
AU - Mokrysz, Claire
AU - Curran, H. Valerie
AU - Saunders, Rob
AU - Freeman, Tom P.
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The findings were mixed, although CBD was found to reduce the effects of THC in several studies. Some studies found that CBD reduced intense experiences of anxiety or psychosis-like effects of THC and blunted some of the impairments on emotion and reward processing. However, CBD did not consistently influence the effects of THC across all studies and outcomes. There was considerable heterogeneity in dose, route of administration and THC:CBD ratio across studies and no clear dose-response profile emerged. Although findings were mixed, this review suggests that CBD may interact with some acute effects of THC.
AB - The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The findings were mixed, although CBD was found to reduce the effects of THC in several studies. Some studies found that CBD reduced intense experiences of anxiety or psychosis-like effects of THC and blunted some of the impairments on emotion and reward processing. However, CBD did not consistently influence the effects of THC across all studies and outcomes. There was considerable heterogeneity in dose, route of administration and THC:CBD ratio across studies and no clear dose-response profile emerged. Although findings were mixed, this review suggests that CBD may interact with some acute effects of THC.
UR - http://www.scopus.com/inward/record.url?scp=85073446068&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2019.09.036
DO - 10.1016/j.neubiorev.2019.09.036
M3 - Review article
C2 - 31580839
AN - SCOPUS:85073446068
VL - 107
SP - 696
EP - 712
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -