How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review

Abigail M. Freeman; Katherine Petrilli; Rachel Lees; Chandni Hindocha; Claire Mokrysz; H. Valerie Curran; Rob Saunders; Tom P. Freeman

doi:10.1016/j.neubiorev.2019.09.036

How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review

Abigail M. Freeman, Katherine Petrilli, Rachel Lees, Chandni Hindocha, Claire Mokrysz, H. Valerie Curran, Rob Saunders, Tom P. Freeman

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

19 Downloads (Pure)

Abstract

The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The findings were mixed, although CBD was found to reduce the effects of THC in several studies. Some studies found that CBD reduced intense experiences of anxiety or psychosis-like effects of THC and blunted some of the impairments on emotion and reward processing. However, CBD did not consistently influence the effects of THC across all studies and outcomes. There was considerable heterogeneity in dose, route of administration and THC:CBD ratio across studies and no clear dose-response profile emerged. Although findings were mixed, this review suggests that CBD may interact with some acute effects of THC.

Original language	English
Pages (from-to)	696-712
Number of pages	17
Journal	Neuroscience and Biobehavioral Reviews
Volume	107
Early online date	30 Sep 2019
DOIs	https://doi.org/10.1016/j.neubiorev.2019.09.036
Publication status	Published - 1 Dec 2019

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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10.1016/j.neubiorev.2019.09.036

NBR_23.9.PDFAccepted author manuscript, 1.1 MBLicence: CC BY-NC-ND

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How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review. / Freeman, Abigail M.; Petrilli, Katherine; Lees, Rachel; Hindocha, Chandni; Mokrysz, Claire; Curran, H. Valerie; Saunders, Rob; Freeman, Tom P.

In: Neuroscience and Biobehavioral Reviews, Vol. 107, 01.12.2019, p. 696-712.

Research output: Contribution to journal › Review article › peer-review

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