How cells change their phenotype

David Tosh, Marko E. Horb

Research output: Chapter or section in a book/report/conference proceedingChapter or section


Until recently, it was thought that once a cell had acquired a stable differentiated state, it could not change its phenotype. We now know this is not the case, and over the past few years a plethora of well-documented examples have been presented whereby already differentiated cells or tissue-specific stem cells have been shown to alter their phenotype to express functional characteristics of a different tissue. In this chapter, we examine evidence for these examples, comment on the underlying cellular and molecular mechanisms, and speculate about possible directions of research.

Original languageEnglish
Title of host publicationEssentials of Stem Cell Biology (3rd ed.)
EditorsR. Lanza, A. Atala
Place of PublicationSan Diego, U. S. A.
Number of pages11
ISBN (Print)9780124095038
Publication statusPublished - 4 Nov 2013


  • Barrett's metaplasia
  • Cell fusion
  • Dedifferentiation
  • Liver-to-pancreas
  • Metaplasia
  • Pancreas-to-liver
  • Transdifferentiation

ASJC Scopus subject areas

  • General Medicine


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