Until recently, it was thought that once a cell had acquired a stable differentiated state, it could not change its phenotype. We now know this is not the case, and over the past few years a plethora of well-documented examples have been presented whereby already differentiated cells or tissue-specific stem cells have been shown to alter their phenotype to express functional characteristics of a different tissue. In this chapter, we examine evidence for these examples, comment on the underlying cellular and molecular mechanisms, and speculate about possible directions of research.
|Title of host publication||Handbook of Stem Cells|
|Subtitle of host publication||Volume 1: Pluripotent Stem Cells (2nd ed.)|
|Editors||A. Atala, R. Lanza|
|Place of Publication||Oxford, U. K.|
|Number of pages||6|
|Publication status||Published - 2012|