How cells change their phenotype

David Tosh, Marko E. Horb

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Until recently, it was thought that once a cell had acquired a stable differentiated state, it could not change its phenotype. We now know this is not the case, and over the past few years a plethora of well-documented examples have been presented whereby already differentiated cells or tissue-specific stem cells have been shown to alter their phenotype to express functional characteristics of a different tissue. In this chapter, we examine evidence for these examples, comment on the underlying cellular and molecular mechanisms, and speculate about possible directions of research.
Original languageEnglish
Title of host publicationHandbook of Stem Cells
Subtitle of host publicationVolume 1: Pluripotent Stem Cells (2nd ed.)
EditorsA. Atala, R. Lanza
Place of PublicationOxford, U. K.
PublisherElsevier
Pages95-100
Number of pages6
ISBN (Electronic)9780123859433
ISBN (Print)9780123859426
Publication statusPublished - 2012

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