How cells change their phenotype

Research output: Contribution to journalArticle

338 Citations (Scopus)

Abstract

Recent attention has focused on the remarkable ability of adult stem cells to produce differentiated cells from embryologically unrelated tissues. This phenomenon is an example of metaplasia and shows that embryological commitments can be reversed or erased under certain circumstances. In some cases, even fully differentiated cells can change their phenotype (transdifferentiation). This review examines recently discovered cases of metaplasia, and speculates on the potential molecular and cellular mechanisms that underlie the switches, and their significance to developmental biology and medicine.
Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalNature Reviews Molecular Cell Biology
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 2002

Fingerprint Dive into the research topics of 'How cells change their phenotype'. Together they form a unique fingerprint.

  • Cite this