How cells change their phenotype

David Tosh; Jonathan M. W. Slack

doi:10.1038/nrm761

How cells change their phenotype

David Tosh, Jonathan M. W. Slack

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

376 Citations (SciVal)

Abstract

Recent attention has focused on the remarkable ability of adult stem cells to produce differentiated cells from embryologically unrelated tissues. This phenomenon is an example of metaplasia and shows that embryological commitments can be reversed or erased under certain circumstances. In some cases, even fully differentiated cells can change their phenotype (transdifferentiation). This review examines recently discovered cases of metaplasia, and speculates on the potential molecular and cellular mechanisms that underlie the switches, and their significance to developmental biology and medicine.

Original language	English
Pages (from-to)	187-194
Number of pages	8
Journal	Nature Reviews Molecular Cell Biology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1038/nrm761
Publication status	Published - Mar 2002

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title = "How cells change their phenotype",

abstract = "Recent attention has focused on the remarkable ability of adult stem cells to produce differentiated cells from embryologically unrelated tissues. This phenomenon is an example of metaplasia and shows that embryological commitments can be reversed or erased under certain circumstances. In some cases, even fully differentiated cells can change their phenotype (transdifferentiation). This review examines recently discovered cases of metaplasia, and speculates on the potential molecular and cellular mechanisms that underlie the switches, and their significance to developmental biology and medicine.",

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AB - Recent attention has focused on the remarkable ability of adult stem cells to produce differentiated cells from embryologically unrelated tissues. This phenomenon is an example of metaplasia and shows that embryological commitments can be reversed or erased under certain circumstances. In some cases, even fully differentiated cells can change their phenotype (transdifferentiation). This review examines recently discovered cases of metaplasia, and speculates on the potential molecular and cellular mechanisms that underlie the switches, and their significance to developmental biology and medicine.

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JO - Nature Reviews Molecular Cell Biology

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How cells change their phenotype

Abstract

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