How a DNA mimic catches and cleaves NF-kB

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Bacterial pathogens use several strategies to infect host cells, one of which involves blocking host defenses. During infection, the bacterial effector proteins GtgA, GogA, PipA, and NleC are injected into host cells by the type III secretion system (T3SS), where they suppress the proinflammatory NF-κB signaling pathway to dampen immune responses. The authors demonstrate that these effectors bind NF-κB via their DNA-mimicking regions and uncover differences in effector sequences and structures explaining the individual specificities of these effectors for distinct NF-κB subunits.

Original languageEnglish
Pages (from-to)15330-15331
Number of pages2
JournalJournal of Biological Chemistry
Volume293
Issue number39
Early online date26 Jul 2018
DOIs
Publication statusPublished - 28 Sep 2018

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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