Host–pathogen interactions: Proline gives insect pathogens the green light

Nick Waterfield

doi:10.1016/j.cub.2009.11.018

Host–pathogen interactions: Proline gives insect pathogens the green light

Nick Waterfield

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (SciVal)

Abstract

How does a quiescent symbiont of a nematode worm know when to turn nasty? Metabolic analysis and genetic knockouts confirm that model insect pathogens can sense L-proline in insect blood. This not only serves as a wake-up call, activating secondary metabolite virulence factors, but also provides an energy source for a metabolic shift appropriate for adaptation to the host environment.

Original language	English
Pages (from-to)	R13-R15
Journal	Current Biology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.cub.2009.11.018
Publication status	Published - 12 Jan 2010

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10.1016/j.cub.2009.11.018

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title = "Host–pathogen interactions: Proline gives insect pathogens the green light",

abstract = "How does a quiescent symbiont of a nematode worm know when to turn nasty? Metabolic analysis and genetic knockouts confirm that model insect pathogens can sense L-proline in insect blood. This not only serves as a wake-up call, activating secondary metabolite virulence factors, but also provides an energy source for a metabolic shift appropriate for adaptation to the host environment.",

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Host–pathogen interactions: Proline gives insect pathogens the green light

Abstract

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RAPID BACTERIAL VIRULENCE ANNOTATION FOR THE POST GENOMIC ER A

A NOVEL TOXIN DELIVERY SYSTEM IN BACTERIA

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Host–pathogen interactions: Proline gives insect pathogens the green light

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RAPID BACTERIAL VIRULENCE ANNOTATION FOR THE POST GENOMIC ER A

A NOVEL TOXIN DELIVERY SYSTEM IN BACTERIA

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