Host–pathogen interactions: Proline gives insect pathogens the green light

Nick Waterfield

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

How does a quiescent symbiont of a nematode worm know when to turn nasty? Metabolic analysis and genetic knockouts confirm that model insect pathogens can sense L-proline in insect blood. This not only serves as a wake-up call, activating secondary metabolite virulence factors, but also provides an energy source for a metabolic shift appropriate for adaptation to the host environment.
Original languageEnglish
Pages (from-to)R13-R15
JournalCurrent Biology
Volume20
Issue number1
DOIs
Publication statusPublished - 12 Jan 2010

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