Hormesis results in trade-offs with immunity

Colin D. McClure, Weihao Zhong, Vicky L Hunt, Fiona M. Chapman, Fiona V. Hill, Nicholas K. Priest

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost-free, artefacts of inbreeding, or come with deleterious side-effects. Here we provide evidence that hormesis results in trade-offs with immunity. We find that a single topical dose of dead spores of the entomopathogenic fungus, Metarhizium robertsii, increases the longevity of the fruit fly, Drosophila melanogaster, without significant decreases in fecundity. We find that hormetic benefits of pathogen challenge are greater in lines which lack key components of anti-fungal immunity (Dif and Turandot M). And, in outbred fly lines, we find that topical pathogen challenge enhances both survival and fecundity, but reduces ability to fight off live infections. The results provide evidence that hormesis is manifested by stress-induced trade-offs with immunity, not cost-free benefits or artefacts of inbreeding. Our findings illuminate mechanisms underlying pathogen-induced life history trade-offs, and indicate that reduced immune function may be an ironic side-effect of the “elixirs of life.”
LanguageEnglish
Pages2225-2233
JournalEvolution
Volume68
Issue number8
DOIs
StatusPublished - Aug 2014

Fingerprint

Hormesis
immunity
Immunity
pathogen
inbreeding
Inbreeding
artifact
fecundity
Diptera
Artifacts
Cost-Benefit Analysis
Fertility
pathogens
adverse effects
Metarhizium
Fungal Structures
toxin
spore
entomopathogenic fungi
life history

Keywords

  • trade-offs
  • Fitness
  • Drosophila melanogaster
  • Hormesis
  • Life history evolution
  • Ecological immunity

Cite this

McClure, C. D., Zhong, W., Hunt, V. L., Chapman, F. M., Hill, F. V., & Priest, N. K. (2014). Hormesis results in trade-offs with immunity. Evolution, 68(8), 2225-2233. https://doi.org/10.1111/evo.12453

Hormesis results in trade-offs with immunity. / McClure, Colin D.; Zhong, Weihao; Hunt, Vicky L; Chapman, Fiona M.; Hill, Fiona V.; Priest, Nicholas K.

In: Evolution, Vol. 68, No. 8, 08.2014, p. 2225-2233.

Research output: Contribution to journalArticle

McClure, CD, Zhong, W, Hunt, VL, Chapman, FM, Hill, FV & Priest, NK 2014, 'Hormesis results in trade-offs with immunity', Evolution, vol. 68, no. 8, pp. 2225-2233. https://doi.org/10.1111/evo.12453
McClure CD, Zhong W, Hunt VL, Chapman FM, Hill FV, Priest NK. Hormesis results in trade-offs with immunity. Evolution. 2014 Aug;68(8):2225-2233. https://doi.org/10.1111/evo.12453
McClure, Colin D. ; Zhong, Weihao ; Hunt, Vicky L ; Chapman, Fiona M. ; Hill, Fiona V. ; Priest, Nicholas K. / Hormesis results in trade-offs with immunity. In: Evolution. 2014 ; Vol. 68, No. 8. pp. 2225-2233.
@article{50d70bf15b1d4169a355f0b34b54f2b4,
title = "Hormesis results in trade-offs with immunity",
abstract = "Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost-free, artefacts of inbreeding, or come with deleterious side-effects. Here we provide evidence that hormesis results in trade-offs with immunity. We find that a single topical dose of dead spores of the entomopathogenic fungus, Metarhizium robertsii, increases the longevity of the fruit fly, Drosophila melanogaster, without significant decreases in fecundity. We find that hormetic benefits of pathogen challenge are greater in lines which lack key components of anti-fungal immunity (Dif and Turandot M). And, in outbred fly lines, we find that topical pathogen challenge enhances both survival and fecundity, but reduces ability to fight off live infections. The results provide evidence that hormesis is manifested by stress-induced trade-offs with immunity, not cost-free benefits or artefacts of inbreeding. Our findings illuminate mechanisms underlying pathogen-induced life history trade-offs, and indicate that reduced immune function may be an ironic side-effect of the “elixirs of life.”",
keywords = "trade-offs, Fitness, Drosophila melanogaster, Hormesis, Life history evolution, Ecological immunity",
author = "McClure, {Colin D.} and Weihao Zhong and Hunt, {Vicky L} and Chapman, {Fiona M.} and Hill, {Fiona V.} and Priest, {Nicholas K.}",
year = "2014",
month = "8",
doi = "10.1111/evo.12453",
language = "English",
volume = "68",
pages = "2225--2233",
journal = "Evolution",
issn = "0014-3820",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Hormesis results in trade-offs with immunity

AU - McClure, Colin D.

AU - Zhong, Weihao

AU - Hunt, Vicky L

AU - Chapman, Fiona M.

AU - Hill, Fiona V.

AU - Priest, Nicholas K.

PY - 2014/8

Y1 - 2014/8

N2 - Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost-free, artefacts of inbreeding, or come with deleterious side-effects. Here we provide evidence that hormesis results in trade-offs with immunity. We find that a single topical dose of dead spores of the entomopathogenic fungus, Metarhizium robertsii, increases the longevity of the fruit fly, Drosophila melanogaster, without significant decreases in fecundity. We find that hormetic benefits of pathogen challenge are greater in lines which lack key components of anti-fungal immunity (Dif and Turandot M). And, in outbred fly lines, we find that topical pathogen challenge enhances both survival and fecundity, but reduces ability to fight off live infections. The results provide evidence that hormesis is manifested by stress-induced trade-offs with immunity, not cost-free benefits or artefacts of inbreeding. Our findings illuminate mechanisms underlying pathogen-induced life history trade-offs, and indicate that reduced immune function may be an ironic side-effect of the “elixirs of life.”

AB - Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost-free, artefacts of inbreeding, or come with deleterious side-effects. Here we provide evidence that hormesis results in trade-offs with immunity. We find that a single topical dose of dead spores of the entomopathogenic fungus, Metarhizium robertsii, increases the longevity of the fruit fly, Drosophila melanogaster, without significant decreases in fecundity. We find that hormetic benefits of pathogen challenge are greater in lines which lack key components of anti-fungal immunity (Dif and Turandot M). And, in outbred fly lines, we find that topical pathogen challenge enhances both survival and fecundity, but reduces ability to fight off live infections. The results provide evidence that hormesis is manifested by stress-induced trade-offs with immunity, not cost-free benefits or artefacts of inbreeding. Our findings illuminate mechanisms underlying pathogen-induced life history trade-offs, and indicate that reduced immune function may be an ironic side-effect of the “elixirs of life.”

KW - trade-offs

KW - Fitness

KW - Drosophila melanogaster

KW - Hormesis

KW - Life history evolution

KW - Ecological immunity

UR - http://dx.doi.org/10.1111/evo.12453

U2 - 10.1111/evo.12453

DO - 10.1111/evo.12453

M3 - Article

VL - 68

SP - 2225

EP - 2233

JO - Evolution

T2 - Evolution

JF - Evolution

SN - 0014-3820

IS - 8

ER -