Hollow and porous hydroxyapatite microspheres prepared with an O/W emulsion by spray freezing method

Qiyao Xiao, Kechao Zhou, Chao Chen, Mingxiang Jiang, Yan Zhang, Hang Luo, Dou Zhang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Microspheres with hollow and/or porous structures have been widely used in various applications. A new method of spraying and freezing emulsions was developed to prepare hollow HA (hydroxyapatite) microspheres with interconnected pores by using PVA (polyvinyl alcohol) as emulsifiers and binders. The relationships between viscosity and shear time or rates were tested and the dispersing stability of oil in water (O/W) emulsions was characterized with comparison to suspensions without the addition of oil phase. The effects of solid loadings of HA and the volume ratio between oil and water on the morphologies of microspheres were investigated. Hollow HA microspheres with particle diameter of ~ 20 μm and pore size of ~ 0.6 μm were successfully obtained by spray freezing method. Besides, drying and sintering processes were crucial to the formation of hollow and porous structures, respectively. The gentamicin loading and releasing of HA porous microspheres with different hollow volumes were tested.

Original languageEnglish
Pages (from-to)1068-1074
Number of pages7
Journal Materials Science and Engineering C - Biomimetics Materials Sensors and Systems
Volume69
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • Emulsions
  • HA microspheres
  • Hollow structures
  • Porous structures

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