HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap

L R Wedderburn; Neil J McHugh; H Chinoy; R G Cooper; F Salway; W E R Ollier; L J McCann; H Varsani; J Dunphy; J North; J E Davidson

doi:10.1093/rheumatology/kem265

HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap

L R Wedderburn, Neil J McHugh, H Chinoy, R G Cooper, F Salway, W E R Ollier, L J McCann, H Varsani, J Dunphy, J North, J E Davidson

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Abstract

We present clinical data, HLA genotyping and serological profiling on a large cohort of JDM patients and a carefully characterized subset of patients with JDM-SSc overlap. The results confirm known HLA associations and extend the knowledge by stratification of data in serological and clinical subgroups. In the future, a combination of serological and genetic typing may allow for better prediction of clinical course and disease subtype in JDM.

Original language	English
Pages (from-to)	1786-1791
Number of pages	6
Journal	Rheumatology
Volume	46
Issue number	12
DOIs	https://doi.org/10.1093/rheumatology/kem265
Publication status	Published - 2007

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Wedderburn, L. R., McHugh, N. J., Chinoy, H., Cooper, R. G., Salway, F., Ollier, W. E. R., McCann, L. J., Varsani, H., Dunphy, J., North, J., & Davidson, J. E. (2007). HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap. Rheumatology, 46(12), 1786-1791. https://doi.org/10.1093/rheumatology/kem265

Wedderburn, LR, McHugh, NJ, Chinoy, H, Cooper, RG, Salway, F, Ollier, WER, McCann, LJ, Varsani, H, Dunphy, J, North, J & Davidson, JE 2007, 'HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap', Rheumatology, vol. 46, no. 12, pp. 1786-1791. https://doi.org/10.1093/rheumatology/kem265

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abstract = "We present clinical data, HLA genotyping and serological profiling on a large cohort of JDM patients and a carefully characterized subset of patients with JDM-SSc overlap. The results confirm known HLA associations and extend the knowledge by stratification of data in serological and clinical subgroups. In the future, a combination of serological and genetic typing may allow for better prediction of clinical course and disease subtype in JDM.",

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AU - Wedderburn, L R

AU - McHugh, Neil J

AU - Chinoy, H

AU - Cooper, R G

AU - Salway, F

AU - Ollier, W E R

AU - McCann, L J

AU - Varsani, H

AU - Dunphy, J

AU - North, J

AU - Davidson, J E

PY - 2007

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N2 - We present clinical data, HLA genotyping and serological profiling on a large cohort of JDM patients and a carefully characterized subset of patients with JDM-SSc overlap. The results confirm known HLA associations and extend the knowledge by stratification of data in serological and clinical subgroups. In the future, a combination of serological and genetic typing may allow for better prediction of clinical course and disease subtype in JDM.

AB - We present clinical data, HLA genotyping and serological profiling on a large cohort of JDM patients and a carefully characterized subset of patients with JDM-SSc overlap. The results confirm known HLA associations and extend the knowledge by stratification of data in serological and clinical subgroups. In the future, a combination of serological and genetic typing may allow for better prediction of clinical course and disease subtype in JDM.

UR - http://dx.doi.org/10.1093/rheumatology/kem265

U2 - 10.1093/rheumatology/kem265

DO - 10.1093/rheumatology/kem265

M3 - Article

SN - 1462-0332

VL - 46

SP - 1786

EP - 1791

JO - Rheumatology

JF - Rheumatology

IS - 12

ER -

HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap

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