Hippocampal Subfield Viscoelasticity in Amnestic Mild Cognitive Impairment Evaluated with MR Elastography

Peyton L. Delgorio; Lucy V. Hiscox; Grace  McIlvain; Mary K. Kramer; Alexa M. Diano; Kyra E. Twohy; Alexis A. Merritt; Matthew D.J. McGarry; Hillary Schwarb; Ana M. Daugherty; James M. Ellison; Alyssa M Lanzi; Matthew L. Cohen; Christopher R. Martens; Curtis L. Johnson

doi:10.1016/j.nicl.2023.103327

Hippocampal Subfield Viscoelasticity in Amnestic Mild Cognitive Impairment Evaluated with MR Elastography

Peyton L. Delgorio, Lucy V. Hiscox, Grace McIlvain, Mary K. Kramer, Alexa M. Diano, Kyra E. Twohy, Alexis A. Merritt, Matthew D.J. McGarry, Hillary Schwarb, Ana M. Daugherty, James M. Ellison, Alyssa M Lanzi, Matthew L. Cohen, Christopher R. Martens, Curtis L. Johnson

Research output: Contribution to journal › Article › peer-review

11 Citations (SciVal)

Abstract

Hippocampal subfields (HCsf) are brain regions important for memory function that are vulnerable to decline with amnestic mild cognitive impairment (aMCI), which is often a preclinical stage of Alzheimer’s disease. Studies in aMCI patients often assess HCsf tissue integrity using measures of volume, which has little specificity to microstructure and pathology. We use magnetic resonance elastography (MRE) to examine the viscoelastic mechanical properties of HCsf tissue, which is related to structural integrity, and sensitively detect differences in older adults with aMCI compared to an age-matched control group. Group comparisons revealed HCsf viscoelasticity is differentially affected in aMCI, with CA1-CA2 and DG-CA3 exhibiting lower stiffness and CA1-CA2 exhibiting higher damping ratio, both indicating poorer tissue integrity in aMCI. Including HCsf stiffness in a logistic regression improves classification of aMCI beyond measures of volume alone. Additionally, lower DG-CA3 stiffness predicted aMCI status regardless of DG-CA3 volume. These findings showcase the benefit of using MRE in detecting subtle pathological tissue changes in individuals with aMCI via the HCsf particularly affected in the disease.

Original language	English
Article number	103327
Journal	Neuroimage Clinical
Volume	37
Early online date	18 Jan 2023
DOIs	https://doi.org/10.1016/j.nicl.2023.103327
Publication status	Published - 31 Jan 2023
Externally published	Yes

Data Availability Statement

Data will be made available on request.

Funding

This research was supported by grants from the National Institutes of Health: R01-AG058853, R01-EB027577, and K01-AG054731. Participant recruitment was organized through the Delaware Center for Cognitive Aging Research.

Funders	Funder number
National Institutes of Health	R01-AG058853, K01-AG054731, R01-EB027577

Keywords

Brain
Hippocampus
Mechanical Properties
Mild Cognitive Impairment
Neurodegeneration
Stiffness

ASJC Scopus subject areas

Clinical Neurology
Neurology
Cognitive Neuroscience
Radiology Nuclear Medicine and imaging

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10.1016/j.nicl.2023.103327Licence: CC BY-NC-ND

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Delgorio, P. L., Hiscox, L. V., McIlvain, G., Kramer, M. K., Diano, A. M., Twohy, K. E., Merritt, A. A., McGarry, M. D. J., Schwarb, H., Daugherty, A. M., Ellison, J. M., Lanzi, A. M., Cohen, M. L., Martens, C. R., & Johnson, C. L. (2023). Hippocampal Subfield Viscoelasticity in Amnestic Mild Cognitive Impairment Evaluated with MR Elastography. Neuroimage Clinical, 37, Article 103327. https://doi.org/10.1016/j.nicl.2023.103327

Delgorio, PL, Hiscox, LV, McIlvain, G, Kramer, MK, Diano, AM, Twohy, KE, Merritt, AA, McGarry, MDJ, Schwarb, H, Daugherty, AM, Ellison, JM, Lanzi, AM, Cohen, ML, Martens, CR & Johnson, CL 2023, 'Hippocampal Subfield Viscoelasticity in Amnestic Mild Cognitive Impairment Evaluated with MR Elastography', Neuroimage Clinical, vol. 37, 103327. https://doi.org/10.1016/j.nicl.2023.103327

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abstract = "Hippocampal subfields (HCsf) are brain regions important for memory function that are vulnerable to decline with amnestic mild cognitive impairment (aMCI), which is often a preclinical stage of Alzheimer{\textquoteright}s disease. Studies in aMCI patients often assess HCsf tissue integrity using measures of volume, which has little specificity to microstructure and pathology. We use magnetic resonance elastography (MRE) to examine the viscoelastic mechanical properties of HCsf tissue, which is related to structural integrity, and sensitively detect differences in older adults with aMCI compared to an age-matched control group. Group comparisons revealed HCsf viscoelasticity is differentially affected in aMCI, with CA1-CA2 and DG-CA3 exhibiting lower stiffness and CA1-CA2 exhibiting higher damping ratio, both indicating poorer tissue integrity in aMCI. Including HCsf stiffness in a logistic regression improves classification of aMCI beyond measures of volume alone. Additionally, lower DG-CA3 stiffness predicted aMCI status regardless of DG-CA3 volume. These findings showcase the benefit of using MRE in detecting subtle pathological tissue changes in individuals with aMCI via the HCsf particularly affected in the disease.",

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AU - Delgorio, Peyton L.

AU - Hiscox, Lucy V.

AU - McIlvain, Grace

AU - Kramer, Mary K.

AU - Diano, Alexa M.

AU - Twohy, Kyra E.

AU - Merritt, Alexis A.

AU - McGarry, Matthew D.J.

AU - Schwarb, Hillary

AU - Daugherty, Ana M.

AU - Ellison, James M.

AU - Lanzi, Alyssa M

AU - Cohen, Matthew L.

AU - Martens, Christopher R.

AU - Johnson, Curtis L.

PY - 2023/1/31

Y1 - 2023/1/31

N2 - Hippocampal subfields (HCsf) are brain regions important for memory function that are vulnerable to decline with amnestic mild cognitive impairment (aMCI), which is often a preclinical stage of Alzheimer’s disease. Studies in aMCI patients often assess HCsf tissue integrity using measures of volume, which has little specificity to microstructure and pathology. We use magnetic resonance elastography (MRE) to examine the viscoelastic mechanical properties of HCsf tissue, which is related to structural integrity, and sensitively detect differences in older adults with aMCI compared to an age-matched control group. Group comparisons revealed HCsf viscoelasticity is differentially affected in aMCI, with CA1-CA2 and DG-CA3 exhibiting lower stiffness and CA1-CA2 exhibiting higher damping ratio, both indicating poorer tissue integrity in aMCI. Including HCsf stiffness in a logistic regression improves classification of aMCI beyond measures of volume alone. Additionally, lower DG-CA3 stiffness predicted aMCI status regardless of DG-CA3 volume. These findings showcase the benefit of using MRE in detecting subtle pathological tissue changes in individuals with aMCI via the HCsf particularly affected in the disease.

AB - Hippocampal subfields (HCsf) are brain regions important for memory function that are vulnerable to decline with amnestic mild cognitive impairment (aMCI), which is often a preclinical stage of Alzheimer’s disease. Studies in aMCI patients often assess HCsf tissue integrity using measures of volume, which has little specificity to microstructure and pathology. We use magnetic resonance elastography (MRE) to examine the viscoelastic mechanical properties of HCsf tissue, which is related to structural integrity, and sensitively detect differences in older adults with aMCI compared to an age-matched control group. Group comparisons revealed HCsf viscoelasticity is differentially affected in aMCI, with CA1-CA2 and DG-CA3 exhibiting lower stiffness and CA1-CA2 exhibiting higher damping ratio, both indicating poorer tissue integrity in aMCI. Including HCsf stiffness in a logistic regression improves classification of aMCI beyond measures of volume alone. Additionally, lower DG-CA3 stiffness predicted aMCI status regardless of DG-CA3 volume. These findings showcase the benefit of using MRE in detecting subtle pathological tissue changes in individuals with aMCI via the HCsf particularly affected in the disease.

KW - Brain

KW - Hippocampus

KW - Mechanical Properties

KW - Mild Cognitive Impairment

KW - Neurodegeneration

KW - Stiffness

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M1 - 103327

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Hippocampal Subfield Viscoelasticity in Amnestic Mild Cognitive Impairment Evaluated with MR Elastography

Abstract

Data Availability Statement

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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