Highly Sensitive Real-Time Isotopic Quantification of Water by ATR-FTIR

Cei B. Provis-Evans, Elliot H.E. Farrar, Matthew N. Grayson, Ruth L. Webster, Alfred K. Hill

Research output: Contribution to journalArticlepeer-review

2 Citations (SciVal)


A method has been developed to reliably quantify the isotopic composition of liquid water, requiring only immersion of a "ReactIR" probe in the sample under test. The accuracy and robustness of this method has been extensively tested using a deuterium/protium system, and substantial improvements in sensitivity were obtained using highly novel chemical signal amplification methods demonstrating a standard deviation of 247 ppb D (a D of 1.6 ‰). This compares favorably with other more costly and time-consuming techniques and is over 20 times more sensitive than any previously published FTIR study. Computational simulations of a model system match the experimental data and show how these methods can be adapted to a tritium/protium system.

Original languageEnglish
Pages (from-to)7500-7507
Number of pages8
JournalAnalytical Chemistry
Issue number11
Early online date29 Apr 2020
Publication statusPublished - 2 Jun 2020

ASJC Scopus subject areas

  • Analytical Chemistry


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