Highly Efficient Gold(I)-Catalyzed Regio- and Stereoselective Hydrocarboxylation of Internal Alkynes

Danila Gasperini, Stéphanie Dupuy, Steven P. Nolan

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

We report the highly efficient gold-catalyzed hydrocarboxylation of internal alkynes that operates under solvent- and silver-free conditions. This new, simple, and eco.friendly protocol allows for the synthesis of a wide variety of functionalized aryl and alkyl enol esters in high yields, with Z-stereospecificity and good regioselectivities and without the requirement for purification by chromatography, This process represents an expedient, operationally simple method for the synthesis of enol esters.
Original languageEnglish
Pages (from-to)6918-6921
Number of pages4
JournalACS Catalysis
Volume5
Issue number11
DOIs
Publication statusPublished - 12 Oct 2015

Keywords

  • alkynes
  • hydrocarboxylation

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