Highlights of the 14th International Bordetella Symposium

Kevin Munoz Navarrete; Kathryn M. Edwards; Kingston H. G. Mills; Jana Kamanová; María Eugenia Rodriguez; Andrew Gorringe; Andrew Preston; Beate Kampmann; Monica C. Gestal; Eric T. Harvill; Purnima Dubey; Dimitri A. Diavatopoulos; Seema Mattoo; Karen M. Scanlon; Camille Locht; Peter Sebo

doi:10.1128/msphere.00189-25

Highlights of the 14th International Bordetella Symposium

Kevin Munoz Navarrete
, Kathryn M. Edwards
, Kingston H. G. Mills
, Jana Kamanová
, María Eugenia Rodriguez
, Andrew Gorringe
, Andrew Preston
, Beate Kampmann
, Monica C. Gestal
, Eric T. Harvill
, Purnima Dubey
, Dimitri A. Diavatopoulos
, Seema Mattoo
, Karen M. Scanlon
, Camille Locht
, Peter Sebo

Academy of Sciences of the Czech Republic
Vanderbilt University Medical Center
Trinity College Dublin
Universidad Nacional de La Plata
UK Health Security Agency, Porton Down
Institute of International Health, Charité - Universitätsmedizin Berlin
London School of Hygiene & Tropical Medicine
Louisiana State University
University of Georgia
Ohio State University
University Medical Centre St. Radboud
Purdue University
University of Maryland
Université Lille 1

Research output: Contribution to journal › Review article › peer-review

4 Citations (SciVal)

Abstract

Pertussis, or whooping cough, is a highly contagious and acute respiratory illness caused primarily by the gram-negative coccobacillus Bordetella pertussis. Despite near-universal vaccination, pertussis remains one of the least-controlled vaccine-preventable infectious diseases. Since 2023, pertussis incidence has been rising, and widespread pertussis outbreaks have resurged in many countries. In response to these emerging challenges, almost 300 experts from institutions across 24 countries convened at the 14th International Bordetella Symposium in Prague, Czech Republic, from 24 to 28 June 2024 to discuss pertussis epidemiology and research and strategies to mitigate the global pertussis burden. We present here the highlights of the symposium, comprising epidemiological and clinical aspects of Bordetella infections, results of clinical trials of pertussis vaccination in pregnant women and effectiveness of maternal vaccination in protecting newborn infants in Africa and Europe, the controlled human infection model (CHIM), and the latest insights into the biology, immunology, and pathogenesis of B. pertussis infection.

Original language	English
Article number	e00189
Number of pages	18
Journal	mSphere
Volume	10
Issue number	6
Early online date	16 May 2025
DOIs	https://doi.org/10.1128/msphere.00189-25
Publication status	Published - 25 Jun 2025

Funding

Funding for this conference was made possible (in part) by 1R13AI183722-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in this publication and presented by the speakers and moderators at the conference do not necessarily reflect the official policies of the Department of Health and Human Services, nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number R13AI183722. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The 14th International Bordetella Symposium would not have been possible without the financial support of the Institute of Microbiology of the Czech Academy of Sciences in Prague and the sponsorship contributions of ILiAD Biotechnologies, GlaxoSmithKline Biologicals SA, Sanofi Pasteur S.A., Dynavax Technologies Corporation, and Moderna CH Inc. Preparation of the conference was supported (in part) by the National Institute of Virology and Bacteriology (Programme EXCELES, ID Project No. LX22NPO5103)—funded by the European Union—Next-Generation EU, the EATRIS project No. LM2023053 (Czech National Node to the European Infrastructure for Translational Medicine) from the Ministry of Education, Youth and Sports of the Czech Republic, and the project Talking microbes—understanding microbial interactions within the One-Health framework. (CZ.02.01.01/00/22_008/0004597).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bordetella pertussis
epidemiology
pathogenesis
toxins
vaccines
virulence

ASJC Scopus subject areas

Microbiology
Molecular Biology

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10.1128/msphere.00189-25Licence: CC BY

Cite this

Munoz Navarrete, K., Edwards, K. M., Mills, K. H. G., Kamanová, J., Rodriguez, M. E., Gorringe, A., Preston, A., Kampmann, B., Gestal, M. C., Harvill, E. T., Dubey, P., Diavatopoulos, D. A., Mattoo, S., Scanlon, K. M., Locht, C., & Sebo, P. (2025). Highlights of the 14th International Bordetella Symposium. mSphere, 10(6), Article e00189. https://doi.org/10.1128/msphere.00189-25

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abstract = "Pertussis, or whooping cough, is a highly contagious and acute respiratory illness caused primarily by the gram-negative coccobacillus Bordetella pertussis. Despite near-universal vaccination, pertussis remains one of the least-controlled vaccine-preventable infectious diseases. Since 2023, pertussis incidence has been rising, and widespread pertussis outbreaks have resurged in many countries. In response to these emerging challenges, almost 300 experts from institutions across 24 countries convened at the 14th International Bordetella Symposium in Prague, Czech Republic, from 24 to 28 June 2024 to discuss pertussis epidemiology and research and strategies to mitigate the global pertussis burden. We present here the highlights of the symposium, comprising epidemiological and clinical aspects of Bordetella infections, results of clinical trials of pertussis vaccination in pregnant women and effectiveness of maternal vaccination in protecting newborn infants in Africa and Europe, the controlled human infection model (CHIM), and the latest insights into the biology, immunology, and pathogenesis of B. pertussis infection.",

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AU - Gorringe, Andrew

AU - Preston, Andrew

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AU - Dubey, Purnima

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AB - Pertussis, or whooping cough, is a highly contagious and acute respiratory illness caused primarily by the gram-negative coccobacillus Bordetella pertussis. Despite near-universal vaccination, pertussis remains one of the least-controlled vaccine-preventable infectious diseases. Since 2023, pertussis incidence has been rising, and widespread pertussis outbreaks have resurged in many countries. In response to these emerging challenges, almost 300 experts from institutions across 24 countries convened at the 14th International Bordetella Symposium in Prague, Czech Republic, from 24 to 28 June 2024 to discuss pertussis epidemiology and research and strategies to mitigate the global pertussis burden. We present here the highlights of the symposium, comprising epidemiological and clinical aspects of Bordetella infections, results of clinical trials of pertussis vaccination in pregnant women and effectiveness of maternal vaccination in protecting newborn infants in Africa and Europe, the controlled human infection model (CHIM), and the latest insights into the biology, immunology, and pathogenesis of B. pertussis infection.

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KW - epidemiology

KW - pathogenesis

KW - toxins

KW - vaccines

KW - virulence

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DO - 10.1128/msphere.00189-25

M3 - Review article

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JF - mSphere

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ER -

Highlights of the 14th International Bordetella Symposium

Abstract

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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