High Aspect Ratio-Nanostructured Surfaces as Biological Metamaterials

Stuart Higgins, Michele Becce, Alexis Belessiotis-Richards, Hyejeong Seong, Julia Sero, Molly Stevens

Research output: Contribution to journalReview article

Abstract

Materials patterned with high aspect ratio nanostructures have features on
similar length scales to cellular components. These surfaces are an extreme
topography on the cellular level and have become useful tools for perturbing
and sensing the cellular environment. Motivation comes from the ability of
high aspect ratio nanostructures to deliver cargoes into cells and tissues,
access the intracellular environment, and control cell behavior. These
structures directly perturb cells’ ability to sense and respond to external
forces, influencing cell fate, and enabling new mechanistic studies. Through
careful design of their nanoscale structure, these systems act as biological
metamaterials, eliciting unusual biological responses. While predominantly
used to interface eukaryotic cells, there is growing interest in nonanimal
and prokaryotic cell interfacing. Both experimental and theoretical studies
have attempted to develop a mechanistic understanding for the observed
behaviors, predominantly focusing on the cell–nanostructure interface.
Here, it is considered how high aspect ratio–nanostructured surfaces are
used to both stimulate and sense biological systems and remaining research
Q5 questions are discussed.
Original languageEnglish
JournalAdvanced Materials
Publication statusAccepted/In press - 2020

Cite this

Higgins, S., Becce, M., Belessiotis-Richards, A., Seong, H., Sero, J., & Stevens, M. (Accepted/In press). High Aspect Ratio-Nanostructured Surfaces as Biological Metamaterials. Advanced Materials.

High Aspect Ratio-Nanostructured Surfaces as Biological Metamaterials. / Higgins, Stuart; Becce, Michele; Belessiotis-Richards, Alexis; Seong, Hyejeong; Sero, Julia; Stevens, Molly.

In: Advanced Materials, 2020.

Research output: Contribution to journalReview article

Higgins, S, Becce, M, Belessiotis-Richards, A, Seong, H, Sero, J & Stevens, M 2020, 'High Aspect Ratio-Nanostructured Surfaces as Biological Metamaterials', Advanced Materials.
Higgins S, Becce M, Belessiotis-Richards A, Seong H, Sero J, Stevens M. High Aspect Ratio-Nanostructured Surfaces as Biological Metamaterials. Advanced Materials. 2020.
Higgins, Stuart ; Becce, Michele ; Belessiotis-Richards, Alexis ; Seong, Hyejeong ; Sero, Julia ; Stevens, Molly. / High Aspect Ratio-Nanostructured Surfaces as Biological Metamaterials. In: Advanced Materials. 2020.
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AU - Belessiotis-Richards, Alexis

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AU - Sero, Julia

AU - Stevens, Molly

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AB - Materials patterned with high aspect ratio nanostructures have features onsimilar length scales to cellular components. These surfaces are an extremetopography on the cellular level and have become useful tools for perturbingand sensing the cellular environment. Motivation comes from the ability ofhigh aspect ratio nanostructures to deliver cargoes into cells and tissues,access the intracellular environment, and control cell behavior. Thesestructures directly perturb cells’ ability to sense and respond to externalforces, influencing cell fate, and enabling new mechanistic studies. Throughcareful design of their nanoscale structure, these systems act as biologicalmetamaterials, eliciting unusual biological responses. While predominantlyused to interface eukaryotic cells, there is growing interest in nonanimaland prokaryotic cell interfacing. Both experimental and theoretical studieshave attempted to develop a mechanistic understanding for the observedbehaviors, predominantly focusing on the cell–nanostructure interface.Here, it is considered how high aspect ratio–nanostructured surfaces areused to both stimulate and sense biological systems and remaining researchQ5 questions are discussed.

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