High Aspect Ratio-Nanostructured Surfaces as Biological Metamaterials

Stuart Higgins; Michele Becce; Alexis Belessiotis-Richards; Hyejeong Seong; Julia Sero; Molly Stevens

doi:10.1002/adma.201903862

High Aspect Ratio-Nanostructured Surfaces as Biological Metamaterials

Stuart Higgins, Michele Becce, Alexis Belessiotis-Richards, Hyejeong Seong, Julia Sero, Molly Stevens

Department of Life Sciences

Imperial College London

Research output: Contribution to journal › Review article › peer-review

178 Citations (SciVal)

185 Downloads (Pure)

Abstract

Materials patterned with high-aspect-ratio nanostructures have features on similar length scales to cellular components. These surfaces are an extreme topography on the cellular level and have become useful tools for perturbing and sensing the cellular environment. Motivation comes from the ability of high-aspect-ratio nanostructures to deliver cargoes into cells and tissues, access the intracellular environment, and control cell behavior. These structures directly perturb cells' ability to sense and respond to external forces, influencing cell fate, and enabling new mechanistic studies. Through careful design of their nanoscale structure, these systems act as biological metamaterials, eliciting unusual biological responses. While predominantly used to interface eukaryotic cells, there is growing interest in nonanimal and prokaryotic cell interfacing. Both experimental and theoretical studies have attempted to develop a mechanistic understanding for the observed behaviors, predominantly focusing on the cell–nanostructure interface. This review considers how high-aspect-ratio nanostructured surfaces are used to both stimulate and sense biological systems.

Original language	English
Article number	1903862
Journal	Advanced Materials
Volume	32
Issue number	9
Early online date	16 Jan 2020
DOIs	https://doi.org/10.1002/adma.201903862
Publication status	Published - 5 Mar 2020

Bibliographical note

Funding Information:
S.G.H. and M.M.S. acknowledge support from the ERC Seventh Framework Programme Consolidator Grant ?Naturale CG' (616417) and a Wellcome Trust Senior Investigator Award (098411/Z/12/Z). M.M.S. and M.B. acknowledge support from The Rosetrees Trust and The Stoneygate Trust. A.B.R. acknowledges a studentship from the EPSRC CDT for the Advanced Characterization of Materials (EP/L015277/1)?. H.S. acknowledges funding from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2017R1A6A3A03007397). S.G.H. acknowledges the many helpful discussions with Dr. Spencer Crowder and colleagues within the Stevens Group; the support of Sabrina Skeete and Dr. Ben Pierce; and Dr. Akemi Nogiwa for extensive proofreading and publishing support. While every attempt was made to locate papers, the authors apologize to any researchers whose work has inadvertently been omitted.

Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

biological metamaterials
high-aspect-ratio nanostructures
nanoneedles
nanopillars
nanowires

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.201903862

nN_Review_Manuscript_ProductionData.PDF
This is the peer reviewed version of the following article: Higgins, S. G., Becce, M., Belessiotis‐Richards, A., Seong, H., Sero, J. E., Stevens, M. M., High‐Aspect‐Ratio Nanostructured Surfaces as Biological Metamaterials. Adv. Mater. 2020, 1903862 which has been published in final form at https://doi.org/10.1002/adma.201903862. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 3.48 MB

Cite this

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abstract = "Materials patterned with high-aspect-ratio nanostructures have features on similar length scales to cellular components. These surfaces are an extreme topography on the cellular level and have become useful tools for perturbing and sensing the cellular environment. Motivation comes from the ability of high-aspect-ratio nanostructures to deliver cargoes into cells and tissues, access the intracellular environment, and control cell behavior. These structures directly perturb cells' ability to sense and respond to external forces, influencing cell fate, and enabling new mechanistic studies. Through careful design of their nanoscale structure, these systems act as biological metamaterials, eliciting unusual biological responses. While predominantly used to interface eukaryotic cells, there is growing interest in nonanimal and prokaryotic cell interfacing. Both experimental and theoretical studies have attempted to develop a mechanistic understanding for the observed behaviors, predominantly focusing on the cell–nanostructure interface. This review considers how high-aspect-ratio nanostructured surfaces are used to both stimulate and sense biological systems.",

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High Aspect Ratio-Nanostructured Surfaces as Biological Metamaterials

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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