Heteroleptic titanium(iv) catecholato/piperazine systems and their anti-cancer properties

Stuart L. Hancock; Rachel Gati; Mary F. Mahon; Edit Y. Tshuva; Matthew D. Jones

doi:10.1039/c3dt52583j

Heteroleptic titanium(iv) catecholato/piperazine systems and their anti-cancer properties

Stuart L. Hancock, Rachel Gati, Mary F. Mahon, Edit Y. Tshuva, Matthew D. Jones

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

14 Citations (SciVal)

82 Downloads (Pure)

Abstract

In this paper we report the synthesis and full characterisation of a range of Ti(IV)-catecholato systems complexed to piperazine or homopiperazine salan ligands. The steric/electronic environment of the catecholate moiety has been varied and the effect this has on cytotoxicity discussed. It was observed that the 7-membered homopiperazine complexes are more stable to hydrolysis than their piperazine cousins in biological media. In general the homopiperazine complexes show higher cytotoxicity than the piperazine complexes, with the most cytotoxic complex exhibiting IC50 (μM) values of 3 ± 0.5 μM (HT-29) and 4 ± 1 μM (OVCAR).

Original language	English
Pages (from-to)	1380-1385
Journal	Dalton Transactions
Volume	43
Issue number	3
DOIs	https://doi.org/10.1039/c3dt52583j
Publication status	Published - 1 Jan 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c3dt52583j

PaperSubmitted manuscript, 1.82 MB

Cite this

@article{f3e233d942e14411b39c2a5495958b22,

title = "Heteroleptic titanium(iv) catecholato/piperazine systems and their anti-cancer properties",

abstract = "In this paper we report the synthesis and full characterisation of a range of Ti(IV)-catecholato systems complexed to piperazine or homopiperazine salan ligands. The steric/electronic environment of the catecholate moiety has been varied and the effect this has on cytotoxicity discussed. It was observed that the 7-membered homopiperazine complexes are more stable to hydrolysis than their piperazine cousins in biological media. In general the homopiperazine complexes show higher cytotoxicity than the piperazine complexes, with the most cytotoxic complex exhibiting IC50 (μM) values of 3 ± 0.5 μM (HT-29) and 4 ± 1 μM (OVCAR).",

author = "Hancock, {Stuart L.} and Rachel Gati and Mahon, {Mary F.} and Tshuva, {Edit Y.} and Jones, {Matthew D.}",

year = "2014",

month = jan,

day = "1",

doi = "10.1039/c3dt52583j",

language = "English",

volume = "43",

pages = "1380--1385",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "3",

}

TY - JOUR

T1 - Heteroleptic titanium(iv) catecholato/piperazine systems and their anti-cancer properties

AU - Hancock, Stuart L.

AU - Gati, Rachel

AU - Mahon, Mary F.

AU - Tshuva, Edit Y.

AU - Jones, Matthew D.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - In this paper we report the synthesis and full characterisation of a range of Ti(IV)-catecholato systems complexed to piperazine or homopiperazine salan ligands. The steric/electronic environment of the catecholate moiety has been varied and the effect this has on cytotoxicity discussed. It was observed that the 7-membered homopiperazine complexes are more stable to hydrolysis than their piperazine cousins in biological media. In general the homopiperazine complexes show higher cytotoxicity than the piperazine complexes, with the most cytotoxic complex exhibiting IC50 (μM) values of 3 ± 0.5 μM (HT-29) and 4 ± 1 μM (OVCAR).

AB - In this paper we report the synthesis and full characterisation of a range of Ti(IV)-catecholato systems complexed to piperazine or homopiperazine salan ligands. The steric/electronic environment of the catecholate moiety has been varied and the effect this has on cytotoxicity discussed. It was observed that the 7-membered homopiperazine complexes are more stable to hydrolysis than their piperazine cousins in biological media. In general the homopiperazine complexes show higher cytotoxicity than the piperazine complexes, with the most cytotoxic complex exhibiting IC50 (μM) values of 3 ± 0.5 μM (HT-29) and 4 ± 1 μM (OVCAR).

UR - http://www.scopus.com/inward/record.url?scp=84890527367&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1039/c3dt52583j

U2 - 10.1039/c3dt52583j

DO - 10.1039/c3dt52583j

M3 - Article

SN - 1477-9226

VL - 43

SP - 1380

EP - 1385

JO - Dalton Transactions

JF - Dalton Transactions

IS - 3

ER -

Heteroleptic titanium(iv) catecholato/piperazine systems and their anti-cancer properties

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this