TY - JOUR
T1 - Heterogeneous catalytic synthesis using microreactor technology
AU - Frost, Christopher G
AU - Mutton, Lynsey
PY - 2010/10
Y1 - 2010/10
N2 - The application of heterogeneous catalysis in conjunction with microreactor technology can facilitate a cleaner and scalable flow methodology for organic synthesis. In this tutorial review we present recent advances in the design of supported catalysts for emerging synthetic applications within microreactor technology. Specifically, transition metal catalysts such as palladium, copper, ruthenium, and nickel are described on silica, monolithic, magnetic nanoparticles and polymer supports. These catalysts have been utilised to promote a range of reactions including Heck, Sonogashira, Suzuki, Kumada, olefin metathesis, hydrogenation and benzannulation reactions.
AB - The application of heterogeneous catalysis in conjunction with microreactor technology can facilitate a cleaner and scalable flow methodology for organic synthesis. In this tutorial review we present recent advances in the design of supported catalysts for emerging synthetic applications within microreactor technology. Specifically, transition metal catalysts such as palladium, copper, ruthenium, and nickel are described on silica, monolithic, magnetic nanoparticles and polymer supports. These catalysts have been utilised to promote a range of reactions including Heck, Sonogashira, Suzuki, Kumada, olefin metathesis, hydrogenation and benzannulation reactions.
UR - http://www.scopus.com/inward/record.url?scp=78149427210&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1039/c0gc00133c
U2 - 10.1039/c0gc00133c
DO - 10.1039/c0gc00133c
M3 - Article
VL - 12
SP - 1687
EP - 1703
JO - Green Chemistry
JF - Green Chemistry
SN - 1463-9262
IS - 10
ER -