Heterocyclic N-4, N-9-diacyl spermines: Nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery

Hassan M Ghonaim; M K Soltan; Ian S Blagbrough

doi:10.1111/j.2042-7158.2010.01178.x

Heterocyclic N-4, N-9-diacyl spermines: Nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery

Hassan M Ghonaim, M K Soltan, Ian S Blagbrough

Department of Life Sciences

Research output: Contribution to journal › Article

Abstract

We are designing and developing lipid-polyamines based upon changes in a series of four N-4, N-9-diacyl spermines (myristoyl, palmitoyl, stearoyl, and oleoyl) each end-capped with the weakly basic nitrogen-containing heterocycles imidazole, pyridine, and quinoline for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression.

Original language	English
Pages (from-to)	1276-1277
Number of pages	2
Journal	Journal of Pharmacy and Pharmacology
Volume	62
Issue number	10
DOIs	https://doi.org/10.1111/j.2042-7158.2010.01178.x
Publication status	Published - Oct 2010
Event	UK PharmSci 2010 - The Science of Medicines - , UK United Kingdom Duration: 1 Sept 2010 → 3 Sept 2010

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abstract = "We are designing and developing lipid-polyamines based upon changes in a series of four N-4, N-9-diacyl spermines (myristoyl, palmitoyl, stearoyl, and oleoyl) each end-capped with the weakly basic nitrogen-containing heterocycles imidazole, pyridine, and quinoline for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression.",

author = "Ghonaim, {Hassan M} and Soltan, {M K} and Blagbrough, {Ian S}",

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AU - Soltan, M K

AU - Blagbrough, Ian S

PY - 2010/10

Y1 - 2010/10

N2 - We are designing and developing lipid-polyamines based upon changes in a series of four N-4, N-9-diacyl spermines (myristoyl, palmitoyl, stearoyl, and oleoyl) each end-capped with the weakly basic nitrogen-containing heterocycles imidazole, pyridine, and quinoline for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression.

AB - We are designing and developing lipid-polyamines based upon changes in a series of four N-4, N-9-diacyl spermines (myristoyl, palmitoyl, stearoyl, and oleoyl) each end-capped with the weakly basic nitrogen-containing heterocycles imidazole, pyridine, and quinoline for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression.

UR - http://dx.doi.org/10.1111/j.2042-7158.2010.01178.x

U2 - 10.1111/j.2042-7158.2010.01178.x

DO - 10.1111/j.2042-7158.2010.01178.x

M3 - Article

SN - 0022-3573

VL - 62

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EP - 1277

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

IS - 10

Y2 - 1 September 2010 through 3 September 2010

ER -

Heterocyclic N-4, N-9-diacyl spermines: Nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery

Abstract

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