We are designing and developing lipid-polyamines based upon changes in a series of four N-4, N-9-diacyl spermines (myristoyl, palmitoyl, stearoyl, and oleoyl) each end-capped with the weakly basic nitrogen-containing heterocycles imidazole, pyridine, and quinoline for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression.
|Number of pages||2|
|Journal||Journal of Pharmacy and Pharmacology|
|Publication status||Published - Oct 2010|
|Event||UK PharmSci 2010 - The Science of Medicines - , UK United Kingdom|
Duration: 1 Sep 2010 → 3 Sep 2010
Ghonaim, H. M., Soltan, M. K., & Blagbrough, I. S. (2010). Heterocyclic N-4, N-9-diacyl spermines: Nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery. Journal of Pharmacy and Pharmacology, 62(10), 1276-1277. https://doi.org/10.1111/j.2042-7158.2010.01178.x