We are designing and developing lipid-polyamines based upon changes in a series of four N-4, N-9-diacyl spermines (myristoyl, palmitoyl, stearoyl, and oleoyl) each end-capped with the weakly basic nitrogen-containing heterocycles imidazole, pyridine, and quinoline for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression.
|Number of pages||2|
|Journal||Journal of Pharmacy and Pharmacology|
|Publication status||Published - Oct 2010|
|Event||UK PharmSci 2010 - The Science of Medicines - , UK United Kingdom|
Duration: 1 Sep 2010 → 3 Sep 2010