Heterocyclic N-4, N-9-diacyl spermines

Nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery

Hassan M Ghonaim, M K Soltan, Ian S Blagbrough

Research output: Contribution to journalArticle

Abstract

We are designing and developing lipid-polyamines based upon changes in a series of four N-4, N-9-diacyl spermines (myristoyl, palmitoyl, stearoyl, and oleoyl) each end-capped with the weakly basic nitrogen-containing heterocycles imidazole, pyridine, and quinoline for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression.
Original languageEnglish
Pages (from-to)1276-1277
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume62
Issue number10
DOIs
Publication statusPublished - Oct 2010
EventUK PharmSci 2010 - The Science of Medicines - , UK United Kingdom
Duration: 1 Sep 20103 Sep 2010

Fingerprint

Spermine
Polyamines
Genetic Therapy
Nanoparticles
Small Interfering RNA
Nitrogen
Lipids
Gene Expression
Genes
imidazole
pyridine
quinoline

Cite this

Heterocyclic N-4, N-9-diacyl spermines : Nanoparticle lipopolyamine vectors for efficient pDNA and siRNA delivery. / Ghonaim, Hassan M; Soltan, M K; Blagbrough, Ian S.

In: Journal of Pharmacy and Pharmacology, Vol. 62, No. 10, 10.2010, p. 1276-1277.

Research output: Contribution to journalArticle

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