Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts

A R Proteggente; S Basu-Modak; G Kuhnle; M J Gordon; K Youdim; R M Tyrrell; C A Rice-Evans

doi:10.1562/0031-8655(2003)0780256HGAPAA2.0.CO2

Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts

A R Proteggente
, S Basu-Modak
, G Kuhnle
, M J Gordon
, K Youdim
, R M Tyrrell
, C A Rice-Evans

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

60 Citations (SciVal)

Abstract

There is considerable interest in the biological properties of flavonoids in terms of their antioxidant and cytoprotective actions. The interaction of the flavanone hesperetin with human skin fibroblasts (FEK4) has revealed the potential for metabolism to hesperetin glucuronide and its subsequent extrusion. As a consequence of this observation, the effectiveness of hesperetin glucuronides, in comparison with that of the aglycone form, in protecting against UV-A radiation has been investigated. The results indicate that hesperetin glucuronides, but not hesperetin, protect against UV-A-induced necrotic cell death.

Original language	English
Pages (from-to)	256-261
Number of pages	6
Journal	Photochemistry and Photobiology
Volume	78
Issue number	3
DOIs	https://doi.org/10.1562/0031-8655(2003)0780256HGAPAA2.0.CO2
Publication status	Published - 2003

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title = "Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts",

abstract = "There is considerable interest in the biological properties of flavonoids in terms of their antioxidant and cytoprotective actions. The interaction of the flavanone hesperetin with human skin fibroblasts (FEK4) has revealed the potential for metabolism to hesperetin glucuronide and its subsequent extrusion. As a consequence of this observation, the effectiveness of hesperetin glucuronides, in comparison with that of the aglycone form, in protecting against UV-A radiation has been investigated. The results indicate that hesperetin glucuronides, but not hesperetin, protect against UV-A-induced necrotic cell death. ",

author = "Proteggente, \{A R\} and S Basu-Modak and G Kuhnle and Gordon, \{M J\} and K Youdim and Tyrrell, \{R M\} and Rice-Evans, \{C A\}",

year = "2003",

doi = "10.1562/0031-8655(2003)0780256HGAPAA2.0.CO2",

language = "English",

volume = "78",

pages = "256--261",

journal = "Photochemistry and Photobiology",

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TY - JOUR

T1 - Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts

AU - Proteggente, A R

AU - Basu-Modak, S

AU - Kuhnle, G

AU - Gordon, M J

AU - Youdim, K

AU - Tyrrell, R M

AU - Rice-Evans, C A

PY - 2003

Y1 - 2003

N2 - There is considerable interest in the biological properties of flavonoids in terms of their antioxidant and cytoprotective actions. The interaction of the flavanone hesperetin with human skin fibroblasts (FEK4) has revealed the potential for metabolism to hesperetin glucuronide and its subsequent extrusion. As a consequence of this observation, the effectiveness of hesperetin glucuronides, in comparison with that of the aglycone form, in protecting against UV-A radiation has been investigated. The results indicate that hesperetin glucuronides, but not hesperetin, protect against UV-A-induced necrotic cell death.

AB - There is considerable interest in the biological properties of flavonoids in terms of their antioxidant and cytoprotective actions. The interaction of the flavanone hesperetin with human skin fibroblasts (FEK4) has revealed the potential for metabolism to hesperetin glucuronide and its subsequent extrusion. As a consequence of this observation, the effectiveness of hesperetin glucuronides, in comparison with that of the aglycone form, in protecting against UV-A radiation has been investigated. The results indicate that hesperetin glucuronides, but not hesperetin, protect against UV-A-induced necrotic cell death.

U2 - 10.1562/0031-8655(2003)0780256HGAPAA2.0.CO2

DO - 10.1562/0031-8655(2003)0780256HGAPAA2.0.CO2

M3 - Article

SN - 0031-8655

VL - 78

SP - 256

EP - 261

JO - Photochemistry and Photobiology

JF - Photochemistry and Photobiology

IS - 3

ER -

Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts

Abstract

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