Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells

Jingyi Gan; Fanwei Meng; Xin Zhou; Chan Li; Yixin He; Xiaoping Zeng; Xingen Jiang; Jia Liu; Guifang Zeng; Yunxia Tang; Muyun Liu; Randall J. Mrsny; Xiang Hu; Jifan Hu; Tao Li

doi:10.1016/j.jcyt.2014.11.011

Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells

Jingyi Gan, Fanwei Meng, Xin Zhou, Chan Li, Yixin He, Xiaoping Zeng, Xingen Jiang, Jia Liu, Guifang Zeng, Yunxia Tang, Muyun Liu, Randall J. Mrsny, Xiang Hu, Jifan Hu, Tao Li

Research output: Contribution to journal › Article › peer-review

19 Citations (SciVal)

Abstract

Background aims: Acute radiation syndrome (ARS) leads to pancytopenia and multi-organ failure. Transplantation of hematopoietic stem cells provides a curative option for radiation-induced aplasia, but this therapy is limited by donor availability. Methods: We examined an alternative therapeutic approach to ARS with the use of human extracellular superoxide dismutase (ECSOD)-modified umbilical cord mesenchymal stromal cells (UCMSCs). This treatment combines the unique regenerative role of UCMSCs with the anti-oxidative activity of ECSOD. Results: We demonstrated that systemically administered ECSOD-UCMSCs are able to protect mice from sub-lethal doses of radiation and improve survival by promoting multilineage hematopoietic recovery. The therapeutic effect of this treatment is related to the decrease in radiation-induced O₂^- and apoptosis. Conclusions: Our data highlight the clinical potential of this two-pronged approach to the treatment of ARS, thereby serving as a rapid and effective first-line strategy to combat the hematopoietic failure resulting from a radiation accident, nuclear terrorism and other radiologic emergencies.

Original language	English
Pages (from-to)	403-417
Number of pages	15
Journal	Cytotherapy
Volume	17
Issue number	4
Early online date	21 Jan 2015
DOIs	https://doi.org/10.1016/j.jcyt.2014.11.011
Publication status	Published - 30 Apr 2015

Bibliographical note

Publisher Copyright:
© 2015 International Society for Cellular Therapy.

Funding

The authors wish to thank Mr Fuping Liu, Director of Dongguan Central Blood Station, for animal irradiation. This study was supported by Shenzhen Research and Development grants ( ZD201111080130A , CXY201107010176A , JSGG20130917151830203 ); a California Institute of Regenerative Medicine (CIRM) grant ( RT2-01942 ), a National Institutes of Health grant ( 1R43 CA103553-01 ), a Department of Defense Grant ( W81XWH-04-1-0597 ), a Jilin International Collaboration Grant (No. 20120720 ), and NSFC grant (No. 81272294 ) to J.F.H.

Funders	Funder number
Jilin International Collaboration	20120720
Shenzhen Research and Development	JSGG20130917151830203, ZD201111080130A, CXY201107010176A
National Institutes of Health
U.S. Department of Defense	W81XWH-04-1-0597
National Cancer Institute	R43CA103553
California Institute for Regenerative Medicine	RT2-01942
National Natural Science Foundation of China	81272294

Keywords

Acute radiation syndrome
Apoptosis
Hematopoietic failure
Stem cell
Superoxide dismutase
Umbilical cord mesenchymal stromal cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology
Genetics(clinical)
Cell Biology
Transplantation
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcyt.2014.11.011

Cite this

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title = "Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells",

abstract = "Background aims: Acute radiation syndrome (ARS) leads to pancytopenia and multi-organ failure. Transplantation of hematopoietic stem cells provides a curative option for radiation-induced aplasia, but this therapy is limited by donor availability. Methods: We examined an alternative therapeutic approach to ARS with the use of human extracellular superoxide dismutase (ECSOD)-modified umbilical cord mesenchymal stromal cells (UCMSCs). This treatment combines the unique regenerative role of UCMSCs with the anti-oxidative activity of ECSOD. Results: We demonstrated that systemically administered ECSOD-UCMSCs are able to protect mice from sub-lethal doses of radiation and improve survival by promoting multilineage hematopoietic recovery. The therapeutic effect of this treatment is related to the decrease in radiation-induced O2- and apoptosis. Conclusions: Our data highlight the clinical potential of this two-pronged approach to the treatment of ARS, thereby serving as a rapid and effective first-line strategy to combat the hematopoietic failure resulting from a radiation accident, nuclear terrorism and other radiologic emergencies.",

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author = "Jingyi Gan and Fanwei Meng and Xin Zhou and Chan Li and Yixin He and Xiaoping Zeng and Xingen Jiang and Jia Liu and Guifang Zeng and Yunxia Tang and Muyun Liu and Mrsny, {Randall J.} and Xiang Hu and Jifan Hu and Tao Li",

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doi = "10.1016/j.jcyt.2014.11.011",

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AU - Gan, Jingyi

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AU - He, Yixin

AU - Zeng, Xiaoping

AU - Jiang, Xingen

AU - Liu, Jia

AU - Zeng, Guifang

AU - Tang, Yunxia

AU - Liu, Muyun

AU - Mrsny, Randall J.

AU - Hu, Xiang

AU - Hu, Jifan

AU - Li, Tao

PY - 2015/4/30

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Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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