Hedgehog signalling

Raymond Teck Ho Lee; Zhonghua Zhao; Philip W Ingham

doi:10.1242/dev.120154

Hedgehog signalling

Raymond Teck Ho Lee, Zhonghua Zhao, Philip W Ingham

Department of Life Sciences

Research output: Contribution to journal › Review article › peer-review

198 Citations (SciVal)

Abstract

The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extends across many fields, from evo-devo to cancer research and regenerative medicine. Here, and in the accompanying poster, we provide an outline of the current understanding of Hh signalling mechanisms, highlighting the similarities and differences between species.

Original language	English
Pages (from-to)	367-72
Number of pages	6
Journal	Development
Volume	143
Issue number	3
DOIs	https://doi.org/10.1242/dev.120154
Publication status	Published - 1 Feb 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Hedgehog Proteins/metabolism
Humans
Invertebrates/metabolism
Signal Transduction
Vertebrates/metabolism

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10.1242/dev.120154

Cite this

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title = "Hedgehog signalling",

abstract = "The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extends across many fields, from evo-devo to cancer research and regenerative medicine. Here, and in the accompanying poster, we provide an outline of the current understanding of Hh signalling mechanisms, highlighting the similarities and differences between species.",

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author = "Lee, \{Raymond Teck Ho\} and Zhonghua Zhao and Ingham, \{Philip W\}",

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AU - Lee, Raymond Teck Ho

AU - Zhao, Zhonghua

AU - Ingham, Philip W

PY - 2016/2/1

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AB - The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extends across many fields, from evo-devo to cancer research and regenerative medicine. Here, and in the accompanying poster, we provide an outline of the current understanding of Hh signalling mechanisms, highlighting the similarities and differences between species.

KW - Animals

KW - Hedgehog Proteins/metabolism

KW - Humans

KW - Invertebrates/metabolism

KW - Signal Transduction

KW - Vertebrates/metabolism

UR - https://www.scopus.com/pages/publications/84956689190

U2 - 10.1242/dev.120154

DO - 10.1242/dev.120154

M3 - Review article

C2 - 26839340

SN - 0950-1991

VL - 143

SP - 367

EP - 372

JO - Development

JF - Development

IS - 3

ER -

Hedgehog signalling

Abstract

UN SDGs

Keywords

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