Heavier alkaline earth catalyzed ene-yne cyclizations: Atom-efficient access to tetrahydroisoquinoline frameworks

Stephanie Reid; Anthony G M Barrett; Michael S. Hill; Panayiotis A. Procopiou

doi:10.1021/ol502600g

Heavier alkaline earth catalyzed ene-yne cyclizations: Atom-efficient access to tetrahydroisoquinoline frameworks

Stephanie Reid, Anthony G M Barrett, Michael S. Hill, Panayiotis A. Procopiou

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Abstract

Tetrahydroisoquinoline frameworks may be accessed with 100% atom efficiency through the alkaline earth catalyzed addition of primary amines to ene-yne substrates through a sequence of intermolecular alkene and intramolecular alkyne hydroamination steps.

Original language	English
Pages (from-to)	6016-6019
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	22
Early online date	10 Nov 2014
DOIs	https://doi.org/10.1021/ol502600g
Publication status	Published - 21 Nov 2014

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10.1021/ol502600g

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This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/ol502600g
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title = "Heavier alkaline earth catalyzed ene-yne cyclizations: Atom-efficient access to tetrahydroisoquinoline frameworks",

abstract = "Tetrahydroisoquinoline frameworks may be accessed with 100% atom efficiency through the alkaline earth catalyzed addition of primary amines to ene-yne substrates through a sequence of intermolecular alkene and intramolecular alkyne hydroamination steps.",

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AU - Procopiou, Panayiotis A.

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UR - http://dx.doi.org/10.1021/ol502600g

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JO - Organic Letters

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Heavier alkaline earth catalyzed ene-yne cyclizations: Atom-efficient access to tetrahydroisoquinoline frameworks

Abstract

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Group 2: Elements of 21st Century Catalysis

MC2- Nuclear Magnetic Resonance (NMR)

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Heavier alkaline earth catalyzed ene-yne cyclizations: Atom-efficient access to tetrahydroisoquinoline frameworks

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Group 2: Elements of 21st Century Catalysis

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MC2- Nuclear Magnetic Resonance (NMR)

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