TY - JOUR
T1 - Health-related utility values of patients with primary Sjögren's syndrome and its predictors
AU - Lendrem, D.
AU - Mitchell, S.
AU - McMeekin, P.
AU - Bowman, S.
AU - Price, E.
AU - Pease, C.T.
AU - Emery, P.
AU - Andrews, J.
AU - Lanyon, P.
AU - Hunter, J.
AU - Gupta, M.
AU - Bombardieri, M.
AU - Sutcliffe, N.
AU - Pitzalis, C.
AU - McLaren, J.
AU - Cooper, A.
AU - Regan, M.
AU - Giles, I.
AU - Isenberg, D.
AU - Vadivelu, S.
AU - Coady, D.
AU - Dasgupta, B.
AU - McHugh, N.
AU - Young-Min, S.
AU - Moots, R.
AU - Gendi, N.
AU - Akil, M.
AU - Griffiths, B.
AU - Ng, W.-F.
PY - 2013/6/12
Y1 - 2013/6/12
N2 - Objectives: EuroQoL-5 dimension (EQ-5D) is a standardised preference-based tool for measurement of health-related quality of life and EQ-5D utility values can be converted to quality-adjusted life years (QALYs) to aid cost-utility analysis. This study aimed to evaluate the EQ-5D utility values of 639 patients with primary Sjögren's syndrome (PSS) in the UK. Methods: Prospective data collected using a standardised pro forma were compared with UK normative data. Relationships between utility values and the clinical and laboratory features of PSS were explored. Results: The proportion of patients with PSS reporting any problem in mobility, self-care, usual activities, pain/discomfort and anxiety/depression were 42.2%, 16.7%, 56.6%, 80.6% and 49.4%, respectively, compared with 5.4%, 1.6%, 7.9%, 30.2% and 15.7% for the UK general population. The median EQ-5D utility value was 0.691 (IQR 0.587-0.796, range -0.239 to 1.000) with a bimodal distribution. Bivariate correlation analysis revealed significant correlations between EQ-5D utility values and many clinical features of PSS, but most strongly with pain, depression and fatigue (R values>0.5). After adjusting for age and sex differences, multiple regression analysis identified pain and depression as the two most important predictors of EQ-5D utility values, accounting for 48% of the variability. Anxiety, fatigue and body mass index were other statistically significant predictors, but they accounted for
AB - Objectives: EuroQoL-5 dimension (EQ-5D) is a standardised preference-based tool for measurement of health-related quality of life and EQ-5D utility values can be converted to quality-adjusted life years (QALYs) to aid cost-utility analysis. This study aimed to evaluate the EQ-5D utility values of 639 patients with primary Sjögren's syndrome (PSS) in the UK. Methods: Prospective data collected using a standardised pro forma were compared with UK normative data. Relationships between utility values and the clinical and laboratory features of PSS were explored. Results: The proportion of patients with PSS reporting any problem in mobility, self-care, usual activities, pain/discomfort and anxiety/depression were 42.2%, 16.7%, 56.6%, 80.6% and 49.4%, respectively, compared with 5.4%, 1.6%, 7.9%, 30.2% and 15.7% for the UK general population. The median EQ-5D utility value was 0.691 (IQR 0.587-0.796, range -0.239 to 1.000) with a bimodal distribution. Bivariate correlation analysis revealed significant correlations between EQ-5D utility values and many clinical features of PSS, but most strongly with pain, depression and fatigue (R values>0.5). After adjusting for age and sex differences, multiple regression analysis identified pain and depression as the two most important predictors of EQ-5D utility values, accounting for 48% of the variability. Anxiety, fatigue and body mass index were other statistically significant predictors, but they accounted for
UR - https://www.scopus.com/pages/publications/84905462421
UR - http://dx.doi.org/10.1136/annrheumdis-2012-202863
U2 - 10.1136/annrheumdis-2012-202863
DO - 10.1136/annrheumdis-2012-202863
M3 - Article
SN - 0003-4967
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
ER -