Harnessing the immunomodulatory effects of exercise to enhance the efficacy of monoclonal antibody therapies against B-cell haematological cancers: a narrative review

Harrison D Collier-Bain, Frankie F. Brown, Adam J. Causer, Annabelle Emery, Rebecca Oliver, Sally Moore, James Murray, James E. Turner, John P. Campbell

Research output: Contribution to journalReview articlepeer-review

2 Citations (SciVal)

Abstract

Therapeutic monoclonal antibodies (mAbs) are standard care for many B-cell haematological cancers. The modes of action for these mAbs include: induction of cancer cell lysis by activating Fcγ-receptors on innate immune cells; opsonising target cells for antibody-dependent cellular cytotoxicity or phagocytosis, and/or triggering the classical complement pathway; the simultaneous binding of cancer cells with T-cells to create an immune synapse and activate perforin-mediated T-cell cytotoxicity against cancer cells; blockade of immune checkpoints to facilitate T-cell cytotoxicity against immunogenic cancer cell clones; and direct delivery of cytotoxic agents via internalisation of mAbs by target cells. While treatment regimens comprising mAb therapy can lead to durable anti-cancer responses, disease relapse is common due to failure of mAb therapy to eradicate minimal residual disease. Factors that limit mAb efficacy include: suboptimal effector cell frequencies, overt immune exhaustion and/or immune anergy, and survival of diffusely spread tumour cells in different stromal niches. In this review, we discuss how immunomodulatory changes arising from exposure to structured bouts of acute exercise might improve mAb treatment efficacy by augmenting (i) antibody-dependent cellular cytotoxicity, (ii) antibody-dependent cellular phagocytosis, (iii) complement-dependent cytotoxicity, (iv) T-cell cytotoxicity, and (v) direct delivery of cytotoxic agents.

Original languageEnglish
Article number1244090
JournalFrontiers in Oncology
Volume13
DOIs
Publication statusPublished - 23 Aug 2023

Bibliographical note

Funding
This review was supported by Cancer Research UK (Grant
number: C60293/A28497).

Keywords

  • B-cells
  • T-cells
  • cancer therapy
  • complement proteins
  • exercise
  • natural killer cells
  • phagocytes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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