H-Comb nanodevices for the study of intracellular forces and mechanical property changes in one-cell embryo development

Marta Duch, Nuria Torras, Maki Asami, Maria Isabel Arjona, Matthew Vermilyea, Robert Castilla, Jose A Plaza, Anthony Perry

Research output: Contribution to conferenceAbstract

Abstract

Intracellular mechanics is a key determinant of cell biology. However, intracellular mechanics are difficult to study in a direct way. Intracellular silicon-based nanodevices open up opportunities to analyze intracellular mechanobiology. A mass production and high reproducility H-comb mechanical sensor microinjected together with the sperm head in an II oocyte allows tracking and quantifying a program of intracellular forces and mechanical properties changes during the first stages of the one-cell mouse embryo, from fertilization to first division. It has been also demonstrated the need of this corresponding fo
Original languageEnglish
Publication statusPublished - 19 Sep 2022
Event48th international conference on Micro and Nano Engineering - Eurosensors (MNE-ES) -
Duration: 19 Sep 2022 → …

Conference

Conference48th international conference on Micro and Nano Engineering - Eurosensors (MNE-ES)
Period19/09/22 → …

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